Kurokawa Junko, Abriel Hugues
Department of Bio-Informational Pharmacology, Medical Research Institute, Tokyo Medical and Dental University, Bunkyo-ku, Tokyo, Japan.
J Cardiovasc Pharmacol. 2009 Aug;54(2):98-105. doi: 10.1097/FJC.0b013e3181b2b6d4.
Alteration of neurohormonal homeostasis is a hallmark of the pathophysiology of chronic heart failure (CHF). In particular, overactivation of the renin-angiotensin-aldosterone system and the sympathetic catecholaminergic system is consistently observed. Chronic overactivation of these hormonal pathways leads to a detrimental arrhythmogenic remodeling of cardiac tissue due to dysregulation of cardiac ion channels. Sudden cardiac death resulting from ventricular arrhythmias is a major cause of mortality in patients with CHF. All the drug classes known to reduce mortality in patients with CHF are neurohormonal blockers. The aim of this review was to provide an overview of how cardiac ion channels are regulated by hormones known to play a central role in the pathogenesis of CHF.
神经激素稳态的改变是慢性心力衰竭（CHF）病理生理学的一个标志。特别是，肾素-血管紧张素-醛固酮系统和交感儿茶酚胺能系统的过度激活一直被观察到。这些激素途径的慢性过度激活由于心脏离子通道的失调导致心脏组织有害的致心律失常重塑。室性心律失常导致的心脏性猝死是CHF患者死亡的主要原因。所有已知可降低CHF患者死亡率的药物类别都是神经激素阻滞剂。本综述的目的是概述在CHF发病机制中起核心作用的激素如何调节心脏离子通道。
