Varadarajulu R, Narayanaswamy A S, Kasthuri A S
Department of Medicine, Armed Forces Medical College, Pune.
J Assoc Physicians India. 1991 May;39(5):377-8.
Four hundred and sixty three patients with malignant diseases were studied over a period of two years; of these, 53 (11.44%) had neurological syndrome, both metastatic (32) and non metastatic (21). The lymphoma-leukaemia group accounted for 34 of the 53 cases. The maximum manifestations were seen in the 21-40 years age group, with male preponderance. The metastatic manifestations were as a result of cerebral (16), brainstem, cerebellar (12) and cord (4) deposits. These were confirmed by CT scan and myelogram. The non metastatic manifestations were peripheral neuropathies (7), leukoencephalopathy and intracranial haemorrhage (6 each), and myasthenic syndrome and myopathy (one each). These findings were confirmed by electrophysiological studies, CT scan, and histopathological examination. Autopsy studies were carried out in 12 of the 53 cases.
在两年的时间里，对463例恶性疾病患者进行了研究；其中，53例（11.44%）出现神经综合征，包括转移性（32例）和非转移性（21例）。淋巴瘤-白血病组占53例中的34例。最大表现见于21至40岁年龄组，男性居多。转移表现是由于脑（16例）、脑干、小脑（12例）和脊髓（4例）沉积所致。这些通过CT扫描和脊髓造影得到证实。非转移表现为周围神经病变（7例）、白质脑病和颅内出血（各6例），以及肌无力综合征和肌病（各1例）。这些发现通过电生理研究、CT扫描和组织病理学检查得到证实。53例中有12例进行了尸检研究。
