Boal Ben W, Schammel Alex W, Garg Neil K
Department of Chemistry and Biochemistry, University of California, Los Angeles, California 90095-1569, USA.
Org Lett. 2009 Aug 6;11(15):3458-61. doi: 10.1021/ol901383j.
An efficient method to access the fused indoline ring system present in a multitude of bioactive molecules has been developed. The strategy involves the condensation of hydrazines with latent aldehydes to ultimately deliver indoline-containing products by way of an interrupted Fischer indolization sequence. Our studies show that the approach will likely be amenable to the synthesis of complex targets, such as the communesin natural products.
已开发出一种有效方法来获取众多生物活性分子中存在的稠合吲哚啉环系统。该策略涉及肼与潜在醛的缩合，最终通过中断的费歇尔吲哚合成序列得到含吲哚啉的产物。我们的研究表明，该方法可能适用于复杂目标分子的合成，如交链孢酚类天然产物。
