Magy Laurent, Vallat Jean-Michel
Service de Neurologie, CHU Limoges, 2 Avenue Martin Luther King, 87042 Limoges Cedex, France.
Expert Opin Pharmacother. 2009 Aug;10(11):1741-54. doi: 10.1517/14656560903036095.
Immune-mediated neuropathies are treatable disorders that can result in considerable disability in some cases. Chronic immune-mediated neuropathies include chronic inflammatory demyelinating polyradiculoneuropathy, multifocal motor neuropathy and neuropathy associated with monoclonal gammopathy. In recent years, therapeutic strategies for these disorders have become clearer as a result of large, randomized controlled trials. However, the treatments used can have serious adverse effects and at least 30% of patients do not respond to conventional therapies. The aim of this paper is to review available data on evidence-based immunotherapy of chronic immune-mediated neuropathies and to summarize recent findings and results obtained with new innovative therapies, such as new immunosuppressants and monoclonal antibodies.
免疫介导性神经病是可治疗的疾病，在某些情况下可导致严重残疾。慢性免疫介导性神经病包括慢性炎症性脱髓鞘性多发性神经根神经病、多灶性运动神经病以及与单克隆丙种球蛋白病相关的神经病。近年来，由于大规模随机对照试验，这些疾病的治疗策略变得更加清晰。然而，所使用的治疗方法可能会产生严重的不良反应，并且至少30%的患者对传统疗法无反应。本文的目的是回顾关于慢性免疫介导性神经病循证免疫治疗的现有数据，并总结新的创新疗法（如新型免疫抑制剂和单克隆抗体）的最新发现和结果。
