静脉注射免疫球蛋白治疗免疫性神经病
Intravenous immunoglobulins in the treatment of immune neuropathies.
作者信息
Kieseier Bernd C, Meyer Zu Hörste Gerd, Lehmann Helmar C, Gold Ralf, Hartung Hans-Peter
机构信息
Department of Neurology, Heinrich-Heine-University, Duesseldorf, Germany.
出版信息
Curr Opin Neurol. 2008 Oct;21(5):555-62. doi: 10.1097/WCO.0b013e32830efc03.
PURPOSE OF REVIEW
The aim of this review is to describe the value of high-dose polyclonal intravenous immunoglobulins as a treatment option in autoimmune disorders affecting the peripheral nervous system.
RECENT FINDINGS
A randomized placebo-controlled trial in patients with chronic inflammatory demyelinating polyradiculoneuropathy revealed short-term and long-term efficacy and safety of intravenous immunoglobulins as a treatment option for the chronically inflamed peripheral nervous system. Case reports suggest that the subcutaneous administration of immunoglobulins may represent a convenient alternative.
SUMMARY
Intravenous immunoglobulin represents an effective and safe treatment option in patients with autoimmune-mediated diseases affecting the peripheral nerves.
综述目的
本综述旨在描述大剂量多克隆静脉注射免疫球蛋白作为一种治疗选择，在影响周围神经系统的自身免疫性疾病中的价值。
最新发现
一项针对慢性炎症性脱髓鞘性多发性神经根神经病患者的随机安慰剂对照试验显示，静脉注射免疫球蛋白作为慢性炎症性周围神经系统的一种治疗选择具有短期和长期疗效及安全性。病例报告表明，皮下注射免疫球蛋白可能是一种方便的替代方法。
总结
静脉注射免疫球蛋白是影响周围神经的自身免疫介导疾病患者的一种有效且安全的治疗选择。
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