Siddall N A, Lin J I, Hime G R, Quinn L M
Department of Anatomy and Cell Biology, University of Melbourne, Parkville 3010, Melbourne, Australia.
Curr Drug Targets. 2009 Jul;10(7):590-601. doi: 10.2174/138945009788680400.
The Myc family proteins are key regulators of animal growth and development. dMyc, the only Drosophila member of the Myc gene family, is orthologous to the mammalian c-Myc oncoprotein. Extensive studies have revealed much about both upstream regulators and downstream target genes in the sphere of Myc regulation. Here, we review some of the critical discoveries made using the Drosophila model, in particular those studies that have explored the essential role of the Myc family in growth and cell cycle progression and identified many of the upstream signals and downstream targets common to both c-Myc and dMyc.
Myc家族蛋白是动物生长和发育的关键调节因子。dMyc是Myc基因家族中唯一的果蝇成员，与哺乳动物的c-Myc癌蛋白是直系同源的。广泛的研究揭示了Myc调控领域中的许多上游调节因子和下游靶基因。在这里，我们回顾一些利用果蝇模型取得的关键发现，特别是那些探索Myc家族在生长和细胞周期进程中的重要作用，并确定了c-Myc和dMyc共有的许多上游信号和下游靶标的研究。
