Nayak Surendra Kumar, Panesar Paramjit Singh, Kumar Harish
Department of Chemistry, Sant Longowal Institute Engineering & Technology (Deemed University), Sangrur, India.
Curr Med Chem. 2009;16(21):2627-40. doi: 10.2174/092986709788681976.
Protein p53 is a key player in mitochondrial mediated apoptotic cell death and excess p53 activity has been implicated in many disease states such athrosclerosis, diabetes, osteoarthritis, Alzheimer's disease, Parkinson's disease, Huntington's disease, AIDS, P. falciparum and S. typhimurium infections. Thus, chemical inhibitors of p53 activation might prove effective in suppressing diseases associated with excess p53 activity. Diverse chemical compounds are being synthesized and evaluated as potent inhibitors of p53 in many cell types. In this review, we have focused on the effects of apoptosis, which is involved in p53 protein and inhibition of p53 induced apoptosis. Peculiar features of p53 protein and its roles in various diseases are summarized along with important inhibitors developed in recent years.
蛋白质p53是线粒体介导的凋亡性细胞死亡中的关键因子，p53活性过高与许多疾病状态有关，如动脉粥样硬化、糖尿病、骨关节炎、阿尔茨海默病、帕金森病、亨廷顿舞蹈症、艾滋病、恶性疟原虫和鼠伤寒沙门氏菌感染。因此，p53激活的化学抑制剂可能在抑制与p53活性过高相关的疾病方面证明是有效的。多种化合物正在被合成并作为许多细胞类型中p53的有效抑制剂进行评估。在这篇综述中，我们重点关注了凋亡的影响，其涉及p53蛋白以及对p53诱导的凋亡的抑制。总结了p53蛋白的独特特征及其在各种疾病中的作用，以及近年来开发的重要抑制剂。
