水飞蓟宾与水飞蓟素在缓冲液和生物流体中的稳定性比较研究。
A comparative study on the stability of silybin and that in silymarin in buffers and biological fluids.
作者信息
Tang Ning, Wu Danni, Lu Yi, Chen Jian, Zhang Bei, Wu Wei
机构信息
School of Pharmacy, Fudan University, Shanghai 201203, China.
出版信息
Drug Metab Lett. 2009 Apr;3(2):115-9. doi: 10.2174/187231209788654072.
PMID:19601873
Abstract
Pure silybin was found to be unstable whilst silybin in silymarin was stable in buffers from pH 1.0 to 7.8. The metabolism of silybin was more severe when in its pure form as compared to silybin in silymarin, as tested in a range of biological fluids including plasma, intestinal fluid and liver homogenates. It would appear that components in silymarin have a stabilization effect on its main component silybin.
摘要
研究发现，纯水飞蓟宾不稳定，而水飞蓟宾在水飞蓟素中，于pH值1.0至7.8的缓冲液中是稳定的。与水飞蓟素中的水飞蓟宾相比，当水飞蓟宾呈纯形式时，其代谢更为严重，这是在包括血浆、肠液和肝匀浆在内的一系列生物流体中进行测试得出的结论。水飞蓟素中的成分似乎对其主要成分水飞蓟宾具有稳定作用。
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