ABAD: a potential therapeutic target for Abeta-induced mitochondrial dysfunction in Alzheimer's disease.
作者信息
Marques A T, Fernandes P A, Ramos M J
机构信息
REQUIMTE, Departamento de Química, Faculdade de Ci ências, Universidade do Porto, Rua do Campo Alegre, 687, 4169-007 Porto, Portugal.
出版信息
Mini Rev Med Chem. 2009 Jul;9(8):1002-8. doi: 10.2174/138955709788681627.
PMID:19601895
Abstract
Amyloid-beta-peptide (Abetabinding to mitochondrial Abeta-binding alcohol dehydrogenase (ABAD) enzyme triggers a series of events leading to mitochondrial dysfunction characteristic of Alzheimer's disease (AD). Thus this interaction may represent a novel target for treatment strategy against AD. In this review we summarize current findings regarding the ABAD-Abeta interaction, namely structural and biophysical data, available inhibitors and more recent data from proteomic studies.
摘要
Zotero 插件