ABAD: a potential therapeutic target for Abeta-induced mitochondrial dysfunction in Alzheimer's disease.

作者信息

Marques A T, Fernandes P A, Ramos M J

机构信息

REQUIMTE, Departamento de Química, Faculdade de Ci ências, Universidade do Porto, Rua do Campo Alegre, 687, 4169-007 Porto, Portugal.

出版信息

Mini Rev Med Chem. 2009 Jul;9(8):1002-8. doi: 10.2174/138955709788681627.

DOI:10.2174/138955709788681627

PMID:19601895

Abstract

Amyloid-beta-peptide (Abetabinding to mitochondrial Abeta-binding alcohol dehydrogenase (ABAD) enzyme triggers a series of events leading to mitochondrial dysfunction characteristic of Alzheimer's disease (AD). Thus this interaction may represent a novel target for treatment strategy against AD. In this review we summarize current findings regarding the ABAD-Abeta interaction, namely structural and biophysical data, available inhibitors and more recent data from proteomic studies.

摘要