Joanne P, Nicolas P, El Amri C
FRE 2852 Protéines: Biochimie Structurale et Fonctionnelle, Université Paris 6-CNRS, Peptidome de la peau d'amphibiens, tour 43, 4, Place Jussieu 75252 Paris cedex 05, France.
Protein Pept Lett. 2009;16(7):743-50. doi: 10.2174/092986609788681814.
Similarly to antimicrobial peptides (AMPs), viral fusion peptides (FPs) are membrane-active peptides. This minireview emphasizes the common properties of AMPs and FPs with a special focus on the intrinsic flexibility and structural adaptability of these peptides that are responsible for different mode of interaction with the membrane bilayers. The potential use of AMPs as multifunctional drugs with both antibacterial and antiviral properties is discussed.
与抗菌肽（AMPs）类似，病毒融合肽（FPs）也是具有膜活性的肽。本综述着重强调了抗菌肽和病毒融合肽的共同特性，特别关注这些肽的内在灵活性和结构适应性，它们负责与膜双层的不同相互作用模式。文中还讨论了抗菌肽作为具有抗菌和抗病毒特性的多功能药物的潜在用途。
