Sandham H J, Brown J, Chan K H, Phillips H I, Burgess R C, Stokl A J
Faculty of Dentistry, University of Toronto, Ontario, Canada.
J Dent Res. 1991 Nov;70(11):1401-8. doi: 10.1177/00220345910700110201.
An abbreviated treatment with a chlorhexidine-containing varnish was compared with a similar treatment with a placebo varnish and with a prophylaxis alone for its effects on the numbers of detectable salivary mutants streptococci in 51 adults. The varnishes, applied once weekly for four weeks, were held in place with a covering layer of either of two polyurethane sealants (FluorProtector or Adhesit). On the first appointment, the varnish-sealant combination was applied to all tooth surfaces, but on succeeding appointments only the occlusal and approximal surfaces were covered. The chlorhexidine varnish, covered with either sealant, reduced the salivary mutans streptococci by an average of 3 logs (99.9%) in all of the 20 subjects treated, and below detectable levels for at least four weeks in nine of them. In the groups receiving placebo varnish-sealant combinations, the mean log number of mutans streptococci of the subjects was reduced only by approximately 0.5 log (32%), and none of the subjects experienced loss of their detectable mutans streptococci for four weeks, although one subject did so for three weeks. No significant difference between the effects of the two polyurethane sealants was observed. Treatment with a single prophylaxis had no effect on mutans streptococcus levels. Subjects treated with chlorhexidine varnish also experienced an increase in S. sanguis and a small decrease in yeasts. Loss of detectable mutans streptococci did not cause changes in the numbers of other micro-organisms examined, beyond those observed with chlorhexidine varnish treatment alone.
将含氯己定的清漆短程治疗与使用安慰剂清漆的类似治疗以及单独进行预防治疗相比较，观察其对51名成年人唾液中可检测到的变形链球菌数量的影响。清漆每周涂抹一次，共四周，并用两种聚氨酯封闭剂（氟保护剂或黏结剂）中的一种覆盖层固定。首次就诊时，清漆 - 封闭剂组合应用于所有牙面，但后续就诊时仅覆盖咬合面和邻面。在接受治疗的所有20名受试者中，无论使用哪种封闭剂覆盖的氯己定清漆，均可使唾液变形链球菌平均减少3个对数（99.9%），其中9名受试者至少四周内降至检测水平以下。在接受安慰剂清漆 - 封闭剂组合治疗的组中，受试者变形链球菌的平均对数仅减少约0.5个对数（32%），尽管有一名受试者在三周内检测不到变形链球菌，但在四周内没有受试者的变形链球菌检测不到。未观察到两种聚氨酯封闭剂的效果有显著差异单人预防治疗对变形链球菌水平没有影响。用氯己定清漆治疗的受试者还出现血链球菌增加和酵母菌略有减少的情况。可检测到的变形链球菌数量减少，除了单独使用氯己定清漆治疗时观察到的变化外，并未引起其他检测微生物数量的改变。
