氟化物漆、氯己定漆和酪蛋白磷酸肽-无定形磷酸钙（CPP-ACP）漆对唾液水平影响的比较：一项为期六个月的临床研究。
Comparison of the Effect of Fluoride Varnish, Chlorhexidine Varnish and Casein Phosphopeptide- Amorphous Calcium Phosphate (CPP-ACP) Varnish on Salivary Level: A Six Month Clinical Study.
作者信息
Patel Punit Manish, Hugar Shivayogi M, Halikerimath Seema, Badakar Chandrashekhar M, Gokhale Niraj S, Thakkar Prachi J, Kohli Divyata, Shah Shreyas
机构信息
Postgraduate Student, Department of Paedodontics and Preventive Dentistry, KLE University's KLE VKIDS, Belagavi, Karnataka, India.
Professor and Head, Department of Paedodontics and Preventive Dentistry, KLE University's KLE VKIDS, Belagavi, Karnataka, India.
出版信息
J Clin Diagn Res. 2017 Aug;11(8):ZC53-ZC59. doi: 10.7860/JCDR/2017/26541.10409. Epub 2017 Aug 1.
INTRODUCTION
Dental caries is the most widespread disease which has a multi factorial origin. is considered to be the chief pathogen in its development. Different varnishes are available which can be used for the prevention of the carious process.
AIM
To compare the effect of fluoride varnish, chlorhexidine varnish and fluoride varnish containing Casein Phosphopeptide - Amorphous Calcium Phosphate (CPP-ACP) on salivary count in children with mixed dentition over a period of six months.
MATERIALS AND METHODS
Seventy two children of age 6-12 years with mixed dentition were selected fulfilling inclusion and exclusion criteria and divided into three groups: Group I- Fluoride varnish group; Group II- Chlorhexidine varnish group; Group III- MI varnish (fluoride varnish containing CPP-ACP) group. After thorough oral prophylaxis and restorative treatment the varnishes were applied to the teeth once a week for four consecutive weeks in the respective groups. Salivary count (CFU/ml of saliva) was estimated at baseline, 1 month, 3 months and 6 months after varnish application. Bonferroni post-hoc test and paired t-test for inter group and intra group comparison was used in the study.
RESULTS
A statistically significant reduction in salivary colony count was seen with all three groups at all the different time intervals. Maximum reduction was noted in chlorhexidine varnish group at all the intervals after varnish application.
CONCLUSION
Prevention of dental caries plays a vital role in paediatric dental practice. The use of dental varnish has proved to be effective in reducing the dental caries. Chlorhexidine varnish was found to show maximum reduction in salivary count for six month period, when compared to MI varnish and fluoride varnish. Thus, chlorhexidine varnish can be used as potent caries inhibiting agent and promote good oral health.
引言
龋齿是最普遍的疾病，其病因是多因素的。 被认为是其发展的主要病原体。有不同的 varnishes 可用于预防龋病过程。
目的
比较氟化物 varnish、洗必泰 varnish 和含酪蛋白磷酸肽 - 无定形磷酸钙（CPP-ACP）的氟化物 varnish 对混合牙列儿童唾液 计数在六个月期间的影响。
材料与方法
选取72名6-12岁混合牙列儿童，符合纳入和排除标准，分为三组：第一组 - 氟化物 varnish 组；第二组 - 洗必泰 varnish 组；第三组 - MI varnish（含 CPP-ACP 的氟化物 varnish）组。在进行彻底的口腔预防和修复治疗后，各组每周对牙齿涂抹一次 varnishes，连续四周。在涂抹 varnish 后的基线、1个月、3个月和6个月时估计唾液 计数（每毫升唾液中的CFU）。研究中使用 Bonferroni 事后检验和配对t检验进行组间和组内比较。
结果
在所有不同时间间隔，三组的唾液 菌落计数均有统计学显著降低。在涂抹 varnish 后的所有间隔，洗必泰 varnish 组的降低幅度最大。
结论
预防龋齿在儿童牙科实践中起着至关重要的作用。使用牙科 varnish 已被证明在减少龋齿方面是有效的。与 MI varnish 和氟化物 varnish 相比，洗必泰 varnish 在六个月期间唾液 计数的降低幅度最大。因此，洗必泰 varnish 可作为有效的龋齿抑制剂，促进良好的口腔健康。
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