Ogawa Masami, Tsumuro Tae, Takubo Miho, Ueda Yuhki, Yatsuzuka Rie, Kishi Yuko, Kamei Chiaki
Preclinical Research Department, Schering-Plough K.K., Osaka, Japan.
Pharmacology. 2009;84(2):99-103. doi: 10.1159/000228727. Epub 2009 Jul 15.
The present study was performed to evaluate the effect of mometasone furoate on a nasal congestion model in Brown Norway rats.
Nasal congestion in rats sensitized with toluene-2,4-diisocyanate (TDI) was measured using whole-body plethysmography which allowed animals to move freely.
Penh (enhanced pause), an index of nasal congestion, was significantly increased after 5% TDI challenge in sensitized rats compared with that in non-sensitized rats. The peak of the increase in Penh appeared at 1 and 5 h after TDI challenge. A single topical administration of mometasone furoate (0.05%) at 1 h before TDI challenge suppressed the increase of Penh in sensitized rats. A significant effect was observed 5-6 h after nasal administration. Almost the same results were obtained with fluticasone propionate (0.05%).
Mometasone furoate may therefore be effective and have a rapid onset of action in nasal congestion when used clinically as with fluticasone propionate.
本研究旨在评估糠酸莫米松对棕色挪威大鼠鼻充血模型的影响。
使用全身体积描记法测量用甲苯-2,4-二异氰酸酯（TDI）致敏的大鼠的鼻充血情况，该方法可使动物自由活动。
与未致敏大鼠相比，致敏大鼠在5%TDI激发后，鼻充血指标Penh（增强停顿）显著升高。Penh升高的峰值出现在TDI激发后1小时和5小时。在TDI激发前1小时单次局部给予糠酸莫米松（0.05%）可抑制致敏大鼠Penh的升高。鼻内给药后5 - 6小时观察到显著效果。使用丙酸氟替卡松（0.05%）也获得了几乎相同的结果。
因此，糠酸莫米松在临床上使用时可能与丙酸氟替卡松一样，对鼻充血有效且起效迅速。
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