Tsumuro Tae, Ogawa Masami, Minami Kazuhisa, Takubo Miho, Rahman Ashequr, Fujii Yoko, Kamei Chiaki
Department of Medicinal Pharmacology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Japan.
Eur J Pharmacol. 2005 Nov 7;524(1-3):155-8. doi: 10.1016/j.ejphar.2005.08.058. Epub 2005 Oct 26.
The present study was undertaken to clarify the effects of mometasone on nasal symptoms induced by repeated intranasal application of antigen in sensitized rats in comparison with that of chlorpheniramine. Rats received mometasone intranasally or chlorpheniramine orally 1 h before a topical antigen challenge for 7 days. Mometasone caused a decrease in the instances of nasal rubbing and an inhibition of this response was observed during the treatment period. Almost identical findings were observed with chlorpheniramine. This response was inhibited, even after the interruption of mometasone treatment, while such an effect was not observed with chlorpheniramine. On day 36, the changes in sensitivity to histamine were investigated. Unlike chlorpheniramine, hypersensitivity to histamine was significantly reduced in the mometasone-treated group. The passive cutaneous anaphylaxis titers were elevated and reached a maximum 8 days after the start of the topical antigen challenge. The passive cutaneous anaphylaxis titer in the mometasone-treated group was significantly lower than that in the control group. The results indicated that mometasone is effective in allergic rhinitis, not only during the period of application, but also after the interruption of application.
本研究旨在阐明与氯苯那敏相比，莫米松对致敏大鼠反复鼻内应用抗原所诱发的鼻部症状的影响。在局部抗原激发前1小时，大鼠鼻内给予莫米松或口服氯苯那敏，持续7天。莫米松使鼻擦次数减少，且在治疗期间观察到该反应受到抑制。氯苯那敏也观察到几乎相同的结果。即使在莫米松治疗中断后，该反应仍受到抑制，而氯苯那敏未观察到这种效果。在第36天，研究了对组胺的敏感性变化。与氯苯那敏不同，莫米松治疗组对组胺的超敏反应显著降低。被动皮肤过敏反应滴度升高，并在局部抗原激发开始后8天达到最大值。莫米松治疗组的被动皮肤过敏反应滴度显著低于对照组。结果表明，莫米松不仅在应用期间，而且在应用中断后对变应性鼻炎均有效。
