Song J C, Sun Y M, Zhang M Z, Yang L Q, Song J G, Wang Z M, Yu W F
Department of Anesthesiology, Eastern Hepatobiliary Surgery Hospital, Second Military Medical University, Shanghai, China.
Curr Drug Deliv. 2009 Jul;6(3):317-20. doi: 10.2174/156720109788680903.
The effect of obstructive jaundice on the distribution and elimination of propofol was studied in 15 patients with obstructive jaundice (total serum bilirubin, TBL >/= 17.1micromol.l(-1)) and in 15 control patients (TBL < 17.1micromol.l(-1)). Following an i.v. bolus dose of propofol (2-2.5 mg.kg(-1)) multiple arterial samples were obtained at timed intervals for 4 h and blood concentrations of propofol were measured by high pressure liquid chromatography. Compartmental analysis of propofol concentrations revealed a three-compartment model with elimination from a central compartment in all patients. Pharmacokinelic parameters: volumes of distribution at steady state (V(SS)), volumes of distribution at equilibrium (V(r)), volumes of the central compartment (V) and total body clearance (Cl) were similar in patients with obstructive jaundice (mean 12.3 (SD 6.0) litre.kg(-1), 32.99(21.42) litre.kg(-1), 0.241(0.131) litre.kg(-1), and 28.8(8.2) ml.min(-1).kg(-1) respectively) compared with contro1 group (11.9 (5.4) litre.kg(-1), 28.30(13.70) litre.kg(-1), 0.297(0.112) litre.kg(-1), and 33.9(7.6) ml.min(-1).kg(-1) respectively) (P>0.05). Half-times of the three phases (T(1/2)(alpha),T(1/2)(beta),T(1/2)(gamma)) were also similar between both groups.We conclude that in patients with obstructive jaundice the pharmacokinetics of propofol are similar to those of patients without obstructive jaundice.
在15例梗阻性黄疸患者（总血清胆红素，TBL≥17.1μmol·L⁻¹）和15例对照患者（TBL＜17.1μmol·L⁻¹）中研究了梗阻性黄疸对丙泊酚分布和消除的影响。静脉注射一剂丙泊酚（2 - 2.5mg·kg⁻¹）后，在4小时内按预定时间间隔采集多个动脉样本，并用高压液相色谱法测定丙泊酚的血药浓度。丙泊酚浓度的房室分析显示，所有患者均为三室模型，药物从中央室消除。药代动力学参数：稳态分布容积（V(SS)）、平衡分布容积（V(r)）、中央室容积（V）和总体清除率（Cl）在梗阻性黄疸患者中分别为12.3（标准差6.0）L·kg⁻¹、32.99(21.42)L·kg⁻¹、0.241(0.131)L·kg⁻¹和28.8(8. )ml·min⁻¹·kg⁻¹，与对照组（分别为11.9（5.4）L·kg⁻¹、28.30(13.70)L·kg⁻¹、0.297(0.112)L·kg⁻¹和33.9(7.6)ml·min⁻¹·kg⁻¹）相比（P＞）。两组的三个相的半衰期（T(1/2)(α)、T(1/2)(β)、T(1/2)(γ)）也相似。我们得出结论，梗阻性黄疸患者丙泊酚的药代动力学与无梗阻性黄疸患者相似。
