Raoof A A, van Obbergh L J, Verbeeck R K
School of Pharmacy, Brussels, Belgium.
Br J Anaesth. 1995 Jan;74(1):46-9. doi: 10.1093/bja/74.1.46.
We studied the pharmacokinetics of an i.v. bolus dose of propofol 2.5-3.0 mg kg-1 in eight children (age 4-24 months) with biliary atresia and in six control (ASA I) children (age 11-43 months). Blood samples were obtained for 4 h after administration of propofol. Blood concentrations of propofol were measured by high pressure liquid chromatography. Systemic clearance of propofol (CI) and volume of distribution at steady state (Vss) showed a highly significant correlation with body weight. Propofol CI and Vss, normalized for body weight, were similar in children with biliary atresia (mean 37.5 (SD 8.3) ml min-1 kg-1 and 3.5 (1.6) litre kg-1, respectively) compared with control children (38.7 (6.8) ml min-1 kg-1 and 2.4 (0.8) litre-1 kg-1, respectively). We conclude that in children with biliary atresia the pharmacokinetics of propofol are similar to those of healthy children.
我们研究了静脉注射2.5 - 3.0毫克/千克丙泊酚推注剂量在8名患有胆道闭锁的儿童（年龄4 - 24个月）和6名对照（ASA I级）儿童（年龄11 - 43个月）中的药代动力学。丙泊酚给药后4小时采集血样。通过高压液相色谱法测量丙泊酚的血药浓度。丙泊酚的全身清除率（CI）和稳态分布容积（Vss）与体重呈高度显著相关性。与对照儿童相比，患有胆道闭锁的儿童经体重标准化后的丙泊酚CI和Vss相似（分别为平均37.5（标准差8.3）毫升/分钟/千克和3.5（1.6）升/千克），对照儿童分别为38.7（6.8）毫升/分钟/千克和2.4（0.8）升/千克。我们得出结论，患有胆道闭锁的儿童丙泊酚的药代动力学与健康儿童相似。
