血管活性肠肽（VIP）对先天性免疫反应的免疫调节作用：其在炎症性疾病中的治疗潜力
Immunomodulation of innate immune responses by vasoactive intestinal peptide (VIP): its therapeutic potential in inflammatory disease.
作者信息
Smalley S G R, Barrow P A, Foster N
机构信息
School of Veterinary Medicine and Science, University of Nottingham, Sutton Bonington Campus, Sutton Bonington, Leicestershire, UK.
出版信息
Clin Exp Immunol. 2009 Aug;157(2):225-34. doi: 10.1111/j.1365-2249.2009.03956.x.
Abstract
Since the late 1970s a number of laboratories have studied the role of vasoactive intestinal peptide (VIP) in inflammation and immunity. These studies have highlighted the dramatic effect of VIP on immune cell activation and function, and studies using animal models of disease have indicated that VIP has significant therapeutic and prophylactic potential. This review will focus on the effects of VIP on innate immune cell function and discuss the therapeutic potential for VIP in inflammatory diseases of humans.
摘要
自20世纪70年代末以来，许多实验室都在研究血管活性肠肽（VIP）在炎症和免疫中的作用。这些研究突出了VIP对免疫细胞激活和功能的显著影响，并且使用疾病动物模型的研究表明VIP具有重大的治疗和预防潜力。本综述将聚焦于VIP对固有免疫细胞功能的影响，并探讨VIP在人类炎症性疾病中的治疗潜力。
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