血管活性肠肽：一种具有多种免疫功能的神经肽。
Vasoactive intestinal peptide: a neuropeptide with pleiotropic immune functions.
机构信息
Instituto de Parasitologia y Biomedicina, IPBLN-CSIC, Granada, Spain.
出版信息
Amino Acids. 2013 Jul;45(1):25-39. doi: 10.1007/s00726-011-1184-8. Epub 2011 Dec 3.
Abstract
Vasoactive intestinal peptide (VIP), a 28-amino acid neuropeptide/neurotransmitter, is widely distributed in both the central and peripheral nervous system. VIP is released by both neurons and immune cells. Various cell types, including immune cells, express VIP receptors. VIP has pleiotropic effects as a neurotransmitter, immune regulator, vasodilator and secretagogue. This review is focused on VIP production and effects on immune cells, VIP receptor signaling as related to immune functions, and the involvement of VIP in inflammatory and autoimmune disorders. The review addresses present clinical use of VIP and future therapeutic directions.
摘要
血管活性肠肽（VIP）是一种 28 个氨基酸的神经肽/神经递质，广泛分布于中枢和外周神经系统。VIP 由神经元和免疫细胞共同释放。多种细胞类型，包括免疫细胞，表达 VIP 受体。VIP 作为神经递质、免疫调节剂、血管扩张剂和分泌素具有多种效应。本文综述了 VIP 在免疫细胞中的产生和作用、与免疫功能相关的 VIP 受体信号转导，以及 VIP 在炎症和自身免疫性疾病中的作用。本文还讨论了 VIP 的目前临床应用和未来治疗方向。
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