Torres María-Dolores, Leiva Marta, Tabar María-Dolores, Naranjo Carolina, Pastor Josep, Peña Teresa
Departament de Medicina i Cirurgia Animals, Facultat de Veterinària, Universitat Autònoma de Barcelona, Barcelona, Spain.
Vet Ophthalmol. 2009 Jul-Aug;12(4):248-53. doi: 10.1111/j.1463-5224.2009.00700.x.
A 1-year-old-female Yorkshire Terrier was referred to the Veterinary Teaching Hospital of the Autonomous University of Barcelona (VTH-UAB) (Spain) with a 6-month history of unilateral chronic proliferative conjunctivitis and intermittent vomiting and cough. Several medical and surgical treatment efforts to manage conjunctival lesions had resulted in no improvement of the clinical signs. Complete general and ophthalmic examinations revealed several proliferative 'wood-like' masses in the conjunctiva, oral cavity and an interscapular subcutaneous nodule. Conjunctival and buccal biopsies were performed as diagnostic procedures. A diagnosis of ligneous conjunctivitis was made on the basis of histopathology findings and clinical presentation. The only biochemical abnormalities found were severe proteinuria and low plasminogen activity in plasma. No other analytical abnormalities were observed. Topical treatment with heparin and anti-inflammatory and immunosuppressive drugs have controlled the ophthalmological clinical signs. To our knowledge, this is the first case report of a dog with plasminogen deficiency and ligneous conjunctivitis with a long survival period and 2-year follow-up.
一只1岁雌性约克夏梗犬被转诊至西班牙巴塞罗那自治大学兽医教学医院（VTH-UAB），有6个月单侧慢性增殖性结膜炎病史，伴有间歇性呕吐和咳嗽。为处理结膜病变进行了多次药物和手术治疗，但临床症状均未改善。全面的全身和眼科检查发现结膜、口腔有多个增殖性“木质样”肿物，肩胛间皮下有一个结节。进行结膜和颊部活检作为诊断程序。根据组织病理学结果和临床表现诊断为木质化结膜炎。唯一发现的生化异常是严重蛋白尿和血浆中纤溶酶原活性降低。未观察到其他分析异常。局部应用肝素以及抗炎和免疫抑制药物已控制了眼科临床症状。据我们所知，这是首例纤溶酶原缺乏且患有木质化结膜炎的犬病例报告，该犬存活期长，并进行了2年随访。
