Hiremath Mandira, Elder James, Newall Fiona, Mitchell Susan, Dyas Roxanne, Monagle Paul
Department of Clinical Haematology, Royal Children's Hospital, Melbourne, Australia.
Blood Coagul Fibrinolysis. 2011 Oct;22(7):606-9. doi: 10.1097/MBC.0b013e3283494b52.
Ligneous conjunctivitis, secondary to inherited homozygous plasminogen deficiency, is a poorly understood condition that has the potential to hinder normal childhood development if not managed adequately. We report the clinical progression of a child with ligneous conjunctivitis, controlled with daily heparin eye drops, postsurgical excision, for a duration of approximately 5 years at a cost of approximately 30 USD per month. During this time, the patient's progress has been complicated by one occurrence of periorbital cellulitis and also otitis media. The patient has also experienced ocular complications due to the remaining membranous lesion. This case indicates that individual patient factors including plasminogen levels and exposure to triggers of ocular inflammation may influence the clinical progression of ligneous conjunctivitis. Furthermore, this study is one of the first to present over 5-year follow-up of a patient with ligneous conjunctivitis effectively managed with long-term heparin eye drops.
木质化性结膜炎继发于遗传性纯合子纤溶酶原缺乏症，是一种了解甚少的病症，如果管理不当，有可能阻碍儿童正常发育。我们报告了一名患有木质化性结膜炎儿童的临床病程，通过每日使用肝素眼药水及手术切除进行控制，持续约5年，每月费用约30美元。在此期间，患者病情因一次眶周蜂窝织炎和一次中耳炎而复杂化。患者还因残留的膜性病变出现了眼部并发症。该病例表明，包括纤溶酶原水平和眼部炎症触发因素暴露在内的个体患者因素可能会影响木质化性结膜炎的临床病程。此外，本研究是首批对使用长期肝素眼药水有效管理的木质化性结膜炎患者进行5年以上随访的研究之一。
