打造世界上最好的助听器；耳蜗中细胞命运的调控。
Building the world's best hearing aid; regulation of cell fate in the cochlea.
作者信息
Puligilla Chandrakala, Kelley Matthew W
机构信息
Section on Developmental Neuroscience, National Institute on Deafness and other Communication Disorders, National Institutes of Health, Bethesda, MD 20892, USA.
出版信息
Curr Opin Genet Dev. 2009 Aug;19(4):368-73. doi: 10.1016/j.gde.2009.06.004. Epub 2009 Jul 13.
Abstract
In mammals, auditory perception is initially mediated through sensory cells located in a rigorously patterned mosaic of unique cell types located within the coiled cochlea. Identification of the factors that direct multipotent progenitor cells to develop as each of these specialized cell types has the potential to enhance our understanding of the development of the auditory system and to identify potential targets for regenerative therapies. Recent results have identified specific signaling molecules and pathways, including Notch, Hedgehog, Sox2 and Fgfs, that guide progenitor cells to develop first as a sensory precursor, referred to as a prosensory cell, and subsequently as one of the specialized cell types within the sensory mosaic.
摘要
在哺乳动物中，听觉感知最初是通过位于卷曲耳蜗内由独特细胞类型构成的严格模式化镶嵌结构中的感觉细胞来介导的。确定引导多能祖细胞发育成这些特殊细胞类型中每一种的因素，有可能增进我们对听觉系统发育的理解，并确定再生疗法的潜在靶点。最近的研究结果已经确定了特定的信号分子和信号通路，包括Notch、Hedgehog、Sox2和Fgf，这些信号分子和信号通路引导祖细胞首先发育成一种感觉前体细胞，即前感觉细胞，随后发育成感觉镶嵌结构中的一种特殊细胞类型。
相似文献
1
Building the world's best hearing aid; regulation of cell fate in the cochlea.打造世界上最好的助听器；耳蜗中细胞命运的调控。
Curr Opin Genet Dev. 2009 Aug;19(4):368-73. doi: 10.1016/j.gde.2009.06.004. Epub 2009 Jul 13.
2
Notch prosensory effects in the Mammalian cochlea are partially mediated by Fgf20.Notch 前体细胞感应效应在哺乳动物耳蜗中部分由 Fgf20 介导。
J Neurosci. 2012 Sep 12;32(37):12876-84. doi: 10.1523/JNEUROSCI.2250-12.2012.
3
Hey1 and Hey2 control the spatial and temporal pattern of mammalian auditory hair cell differentiation downstream of Hedgehog signaling.Hey1 和 Hey2 控制 Hedgehog 信号下游哺乳动物听觉毛细胞分化的时空模式。
J Neurosci. 2014 Sep 17;34(38):12865-76. doi: 10.1523/JNEUROSCI.1494-14.2014.
4
Sox2 signaling in prosensory domain specification and subsequent hair cell differentiation in the developing cochlea.Sox2信号在发育中的耳蜗感觉前体细胞区域特化及随后的毛细胞分化过程中的作用
Proc Natl Acad Sci U S A. 2008 Nov 25;105(47):18396-401. doi: 10.1073/pnas.0808175105. Epub 2008 Nov 14.
5
The RNA-binding protein LIN28B regulates developmental timing in the mammalian cochlea.RNA结合蛋白LIN28B调节哺乳动物耳蜗的发育时间。
Proc Natl Acad Sci U S A. 2015 Jul 21;112(29):E3864-73. doi: 10.1073/pnas.1501077112. Epub 2015 Jul 2.
6
Hedgehog signaling regulates prosensory cell properties during the basal-to-apical wave of hair cell differentiation in the mammalian cochlea. hedgehog 信号在哺乳动物耳蜗毛细胞分化的基底到顶端波中调节前感觉细胞的特性。
Development. 2013 Sep;140(18):3848-57. doi: 10.1242/dev.095398. Epub 2013 Aug 14.
7
Specification of cell fate in the mammalian cochlea.哺乳动物耳蜗中细胞命运的特化。
Birth Defects Res C Embryo Today. 2009 Sep;87(3):212-21. doi: 10.1002/bdrc.20154.
8
Rbpj regulates development of prosensory cells in the mammalian inner ear.Rbpj 调节哺乳动物内耳前体细胞的发育。
Dev Biol. 2011 May 15;353(2):367-79. doi: 10.1016/j.ydbio.2011.03.016. Epub 2011 Mar 21.
9
Notch signaling alters sensory or neuronal cell fate specification of inner ear stem cells.Notch 信号改变内耳干细胞的感觉或神经元细胞命运特化。
J Neurosci. 2011 Jun 8;31(23):8351-8. doi: 10.1523/JNEUROSCI.6366-10.2011.
10
Sox2 in the differentiation of cochlear progenitor cells.Sox2在耳蜗祖细胞分化中的作用
Sci Rep. 2016 Mar 18;6:23293. doi: 10.1038/srep23293.
引用本文的文献
1
Didelphis albiventris: an overview of unprecedented transcriptome sequencing of the white-eared opossum.白耳负鼠：前所未有的白耳负鼠转录组测序概述。
BMC Genomics. 2019 Nov 15;20(1):866. doi: 10.1186/s12864-019-6240-x.
2
Trans-differentiation of outer hair cells into inner hair cells in the absence of INSM1.在外毛细胞中缺失 INSM1 的情况下向内毛细胞的转分化。
Nature. 2018 Nov;563(7733):691-695. doi: 10.1038/s41586-018-0570-8. Epub 2018 Oct 10.
3
The histone demethylase LSD1 regulates inner ear progenitor differentiation through interactions with Pax2 and the NuRD repressor complex.组蛋白去甲基化酶LSD1通过与Pax2和NuRD阻遏复合物相互作用来调节内耳祖细胞的分化。
PLoS One. 2018 Jan 25;13(1):e0191689. doi: 10.1371/journal.pone.0191689. eCollection 2018.
4
Culture of embryonic mouse cochlear explants and gene transfer by electroporation.胚胎小鼠耳蜗外植体的培养及电穿孔基因转移
J Vis Exp. 2015 Jan 12(95):52260. doi: 10.3791/52260.
5
The myc road to hearing restoration.通往听力恢复的霉菌之路。
Cells. 2012 Sep 25;1(4):667-98. doi: 10.3390/cells1040667.
6
The genetics of hair cell development and regeneration.毛细胞发育和再生的遗传学。
Annu Rev Neurosci. 2013 Jul 8;36:361-81. doi: 10.1146/annurev-neuro-062012-170309. Epub 2013 May 29.
7
Making connections in the inner ear: recent insights into the development of spiral ganglion neurons and their connectivity with sensory hair cells.在内耳建立连接：关于螺旋神经节神经元发育及其与感觉毛细胞连接的最新见解。
Semin Cell Dev Biol. 2013 May;24(5):460-9. doi: 10.1016/j.semcdb.2013.04.003. Epub 2013 May 6.
8
An in vitro mouse model of congenital cytomegalovirus-induced pathogenesis of the inner ear cochlea.先天性巨细胞病毒诱导的内耳耳蜗发病机制的体外小鼠模型。
Birth Defects Res A Clin Mol Teratol. 2013 Feb;97(2):69-78. doi: 10.1002/bdra.23105. Epub 2012 Dec 26.
9
Beyond generalized hair cells: molecular cues for hair cell types.超越普通的毛细胞：毛细胞类型的分子线索。
Hear Res. 2013 Mar;297:30-41. doi: 10.1016/j.heares.2012.11.008. Epub 2012 Nov 27.
10
Correct timing of proliferation and differentiation is necessary for normal inner ear development and auditory hair cell viability.正确的增殖和分化时间对于正常内耳发育和听觉毛细胞活力是必要的。
Dev Dyn. 2013 Feb;242(2):132-47. doi: 10.1002/dvdy.23910.
本文引用的文献
1
Sox2 signaling in prosensory domain specification and subsequent hair cell differentiation in the developing cochlea.Sox2信号在发育中的耳蜗感觉前体细胞区域特化及随后的毛细胞分化过程中的作用
Proc Natl Acad Sci U S A. 2008 Nov 25;105(47):18396-401. doi: 10.1073/pnas.0808175105. Epub 2008 Nov 14.
2
Functional auditory hair cells produced in the mammalian cochlea by in utero gene transfer.通过子宫内基因转移在哺乳动物耳蜗中产生的功能性听觉毛细胞。
Nature. 2008 Sep 25;455(7212):537-41. doi: 10.1038/nature07265. Epub 2008 Aug 27.
3
Eya1 gene dosage critically affects the development of sensory epithelia in the mammalian inner ear.Eya1基因剂量严重影响哺乳动物内耳感觉上皮的发育。
Hum Mol Genet. 2008 Nov 1;17(21):3340-56. doi: 10.1093/hmg/ddn229. Epub 2008 Aug 4.
4
Hedgehog signaling regulates sensory cell formation and auditory function in mice and humans.刺猬信号通路调节小鼠和人类的感觉细胞形成及听觉功能。
J Neurosci. 2008 Jul 16;28(29):7350-8. doi: 10.1523/JNEUROSCI.0312-08.2008.
5
Jxc1/Sobp, encoding a nuclear zinc finger protein, is critical for cochlear growth, cell fate, and patterning of the organ of corti.编码一种核锌指蛋白的Jxc1/Sobp对耳蜗生长、细胞命运及柯蒂氏器的模式形成至关重要。
J Neurosci. 2008 Jun 25;28(26):6633-41. doi: 10.1523/JNEUROSCI.1280-08.2008.
6
Fgf20 is required for sensory epithelial specification in the developing cochlea.成纤维细胞生长因子20（Fgf20）是发育中的耳蜗感觉上皮特化所必需的。
J Neurosci. 2008 Jun 4;28(23):5991-9. doi: 10.1523/JNEUROSCI.1690-08.2008.
7
Bmp4 is essential for the formation of the vestibular apparatus that detects angular head movements.骨形态发生蛋白4（Bmp4）对于检测头部角向运动的前庭器官的形成至关重要。
PLoS Genet. 2008 Apr 11;4(4):e1000050. doi: 10.1371/journal.pgen.1000050.
8
Hesr1 and Hesr2 may act as early effectors of Notch signaling in the developing cochlea.Hesr1和Hesr2可能作为发育中的耳蜗中Notch信号通路的早期效应分子发挥作用。
Dev Biol. 2008 Apr 1;316(1):87-99. doi: 10.1016/j.ydbio.2008.01.006. Epub 2008 Jan 18.
9
Fgf8 induces pillar cell fate and regulates cellular patterning in the mammalian cochlea.成纤维细胞生长因子8（Fgf8）诱导柱状细胞命运并调节哺乳动物耳蜗中的细胞模式。
Development. 2007 Aug;134(16):3021-9. doi: 10.1242/dev.02874. Epub 2007 Jul 18.
10
Expression of LHX3 and SOX2 during mouse inner ear development.LHX3和SOX2在小鼠内耳发育过程中的表达。
Gene Expr Patterns. 2007 Aug;7(7):798-807. doi: 10.1016/j.modgep.2007.05.002. Epub 2007 May 26.
Zotero 插件