Puligilla Chandrakala, Kelley Matthew W
Section on Developmental Neuroscience, National Institute on Deafness and other Communication Disorders, National Institutes of Health, Bethesda, MD 20892, USA.
Curr Opin Genet Dev. 2009 Aug;19(4):368-73. doi: 10.1016/j.gde.2009.06.004. Epub 2009 Jul 13.
In mammals, auditory perception is initially mediated through sensory cells located in a rigorously patterned mosaic of unique cell types located within the coiled cochlea. Identification of the factors that direct multipotent progenitor cells to develop as each of these specialized cell types has the potential to enhance our understanding of the development of the auditory system and to identify potential targets for regenerative therapies. Recent results have identified specific signaling molecules and pathways, including Notch, Hedgehog, Sox2 and Fgfs, that guide progenitor cells to develop first as a sensory precursor, referred to as a prosensory cell, and subsequently as one of the specialized cell types within the sensory mosaic.
在哺乳动物中，听觉感知最初是通过位于卷曲耳蜗内由独特细胞类型构成的严格模式化镶嵌结构中的感觉细胞来介导的。确定引导多能祖细胞发育成这些特殊细胞类型中每一种的因素，有可能增进我们对听觉系统发育的理解，并确定再生疗法的潜在靶点。最近的研究结果已经确定了特定的信号分子和信号通路，包括Notch、Hedgehog、Sox2和Fgf，这些信号分子和信号通路引导祖细胞首先发育成一种感觉前体细胞，即前感觉细胞，随后发育成感觉镶嵌结构中的一种特殊细胞类型。
