大鼠脑中高亲和力L-色氨酸摄取的区域分布。
Regional distribution of high-affinity L-tryptophan uptake in rat brain.
作者信息
Höckel S H, Müller W E, Wollert U
机构信息
Pharmakologisches Institut der Universität Mainz, Obere Zahlbacher Str. 67, D-6500 Mainz G.F.R.
出版信息
Neurosci Lett. 1978 Apr;8(1):65-9. doi: 10.1016/0304-3940(78)90099-x.
L-tryptophan is accumulated by slices of seven regions of the rat brain in a saturable, energy-depending fashion, with K(m)-values ranging from 53 to 142 muM. The maximal number of L-tryptophan accumulating sites differs only by about two-fold for the brain regions investigated. The regional distribution of the high-affinity L-tryptophan uptake does not correlate with the amount of serotonin synaptosomal uptake and apparent receptor binding. It is assumed that a specific role of the L-tryptophan uptake system within the serotoninergic system in the brain is questionable.
L-色氨酸以一种可饱和的、依赖能量的方式被大鼠脑七个区域的切片所积累，其米氏常数（K(m)）值范围为53至142微摩尔。在所研究的脑区域中，L-色氨酸积累位点的最大数量仅相差约两倍。高亲和力L-色氨酸摄取的区域分布与血清素突触体摄取量和表观受体结合不相关。据推测，脑中血清素能系统内L-色氨酸摄取系统的特定作用值得怀疑。
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