Borhani Amir A, Hosseinzadeh Keyanoosh, Almusa Omar, Furlan Alessandro, Nalesnik Michael
Department of Diagnostic Imaging, University of Pittsburgh Medical Center (Presbyterian Campus), 200 Lothrop St, CHP MT Suite 3850, Pittsburgh, PA 15213, USA.
Radiographics. 2009 Jul-Aug;29(4):981-1000; discussion 1000-2. doi: 10.1148/rg.294095020.
Posttransplantation lymphoproliferative disorders (PTLDs) are a heterogeneous group of diseases that represent uncommon complications of transplantation and can lead to significant morbidity and mortality. PTLD is most prevalent during the first year following transplantation and occurs most frequently in multiorgan transplant recipients, followed by bowel, heart-lung, and lung recipients. It may involve any of the organ systems, with disease manifestation and the anatomic pattern of organ involvement being highly dependent on the type of transplantation. The current classification system includes four subtypes that have different prognoses requiring different treatment strategies. Tissue sampling is necessary for diagnosis and further subcategorization. The majority of cases are characterized by B-cell proliferation and are related to infection from Epstein-Barr virus. Knowledge of the distribution and radiologic features of PTLD allows the radiologist to play a pivotal role in making an early diagnosis and in guiding biopsy.
移植后淋巴组织增生性疾病（PTLD）是一组异质性疾病，是移植后不常见的并发症，可导致显著的发病率和死亡率。PTLD在移植后的第一年最为常见，最常发生于多器官移植受者，其次是肠道、心肺和肺移植受者。它可能累及任何器官系统，疾病表现和器官受累的解剖模式高度依赖于移植类型。目前的分类系统包括四种亚型，它们具有不同的预后，需要不同的治疗策略。组织取样对于诊断和进一步细分是必要的。大多数病例以B细胞增殖为特征，与EB病毒感染有关。了解PTLD的分布和影像学特征有助于放射科医生在早期诊断和引导活检方面发挥关键作用。
