Loimer N, Presslich O, Grünberger J, Linzmayer L
Department of Psychiatry, University of Vienna, Austria.
J Subst Abuse Treat. 1991;8(3):157-60. doi: 10.1016/0740-5472(91)90007-w.
Every opportunity should be used to reduce the risk of HIV-1 infection and transmission among intravenous drug users (IVDUs). Methadone maintenance is widely accepted to keep the drug user away from risk-laden practices and to stop intravenous drug use. In order to minimize the diversion and intravenous abuse of methadone in maintenance programs, the effects of a combined naloxone/methadone preparation through oral intake and the effects of an intravenous administration were tested. In opiate addicts, the intravenous administration of this mixture caused a severe withdrawal syndrome lasting for 15 to 30 minutes. The oral administration of this combination was indistinguishable from methadone alone. It is argued that this combination therapy prevents the intravenous abuse of methadone in maintenance programs.
应利用一切机会降低静脉吸毒者中艾滋病毒-1感染和传播的风险。美沙酮维持疗法被广泛认可可使吸毒者远离高风险行为并停止静脉吸毒。为尽量减少美沙酮在维持治疗项目中的转移和静脉滥用，对纳洛酮/美沙酮联合制剂口服给药的效果以及静脉给药的效果进行了测试。在阿片类成瘾者中，静脉注射这种混合物会引发持续15至30分钟的严重戒断综合征。口服这种组合制剂的效果与单独服用美沙酮无异。有人认为，这种联合疗法可防止美沙酮在维持治疗项目中的静脉滥用。
