Boston University School of Medicine, Clinical Addiction Research Education Unit, Section of General Internal Medicine, Boston, MA 02118, USA.
J Subst Abuse Treat. 2013 Feb;44(2):241-7. doi: 10.1016/j.jsat.2012.07.004. Epub 2012 Sep 12.
Overdose education and naloxone distribution (OEND) is an intervention that addresses overdose, but has not been studied among people who take methadone, a drug involved in increasing numbers of overdoses. This study describes the implementation of OEND among people taking methadone in the previous 30 days in various settings in Massachusetts. From 2008 to 2010, 1553 participants received OEND who had taken methadone in the past 30 days. Settings included inpatient detoxification (47%), HIV prevention programs (25%), methadone maintenance treatment programs (MMTP) (17%), and other settings (11%). Previous overdose, recent inpatient detoxification and incarceration, and polysubstance use were overdose risks factors common among all groups. Participants reported 92 overdose rescues. OEND programs are public health interventions that address overdose risk among people who take methadone and their social networks. OEND programs can be implemented in MMTPs, detoxification programs, and HIV prevention programs.
过量用药教育和纳洛酮分发（OEND）是一种针对过量用药的干预措施，但尚未在使用美沙酮（一种与越来越多的过量用药有关的药物）的人群中进行研究。本研究描述了在马萨诸塞州的各种环境中，在过去 30 天内使用美沙酮的人群中实施 OEND 的情况。2008 年至 2010 年，共有 1553 名在过去 30 天内服用过美沙酮的参与者接受了 OEND。设置包括住院戒毒（47%）、艾滋病毒预防计划（25%）、美沙酮维持治疗计划（MMTP）（17%）和其他设置（11%）。以前的过量用药、最近的住院戒毒和监禁以及多种物质使用是所有人群中常见的过量用药风险因素。参与者报告了 92 次过量用药抢救。OEND 计划是公共卫生干预措施，可针对使用美沙酮及其社交网络的人群中的过量用药风险。OEND 计划可在 MMTP、戒毒计划和艾滋病毒预防计划中实施。
