国际糖尿病联盟（IDF）的定义更适合用于筛查亚裔美国成年人的代谢综合征及评估糖尿病风险：来自2011 - 2016年美国国家健康与营养检查调查（NHANES）的证据。
The IDF Definition Is Better Suited for Screening Metabolic Syndrome and Estimating Risks of Diabetes in Asian American Adults: Evidence from NHANES 2011-2016.
作者信息
Zhu Lin, Spence Cody, Yang Jenny Wei, Ma Grace X
机构信息
Center for Asian Health, Lewis Katz School of Medicine, Temple University, Philadelphia, PA 19140, USA.
Department of Sociology, College of Liberal Art, Temple University, Philadelphia, PA 19122, USA.
出版信息
J Clin Med. 2020 Nov 28;9(12):3871. doi: 10.3390/jcm9123871.
OBJECTIVE
extensive effort has been made to better define metabolic syndrome (MetS). Whether current definitions accurately diagnose MetS and predict risk of cardiovascular disease (CVD) or diabetes in diverse ethnic groups remains largely unknown. The objective of this study was to compare the prevalence of MetS and risk of CVD and diabetes among Asian American adults using two MetS definitions, one proposed by the Third Report of the National Cholesterol Education Program Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (ATP III) and one by the International Diabetes Federation (IDF).
METHODS
we obtained a nationally representative sample of 2121 Asian American adults in the noninstitutionalized civilian population of the United States from the National Health and Nutrition Examination Survey (2011-2016). We computed age-adjusted, gender-specific MetS prevalence and each MetS component using ATP III and IDF definitions.
RESULTS
based on the IDF definition, MetS prevalence was 39.26% among Asian American men and 39.66% among Asian American women included in the study sample. Based on the ATP III definition, MetS prevalence in our sample was 39.38% among men and 36.11% among women. We found good concordance between the IDF and the ATP III definitions in identifying MetS in Asian American adults. Those with MetS defined only by the IDF definition had significantly higher body mass index (BMI) and waist circumference than those with MetS defined only by the ATP III definition. The IDF definition also better predicted elevated fasting insulin.
CONCLUSIONS
the IDF definition is more pertinent than the ATP III definition for screening and estimating risk of CVD and diabetes in Asian American adults. Future studies should examine differences in MetS prevalence across Asian ethnic groups to facilitate the development of culturally tailored strategies improve MetS prevention and detection in Asian Americans.
目的
为更好地定义代谢综合征（MetS）已付出巨大努力。目前的定义能否准确诊断MetS并预测不同种族群体患心血管疾病（CVD）或糖尿病的风险，在很大程度上仍不清楚。本研究的目的是使用两种MetS定义，比较亚裔美国成年人中MetS的患病率以及CVD和糖尿病的风险，其中一种定义由美国国家胆固醇教育计划成人高胆固醇检测、评估和治疗专家小组第三次报告（ATP III）提出，另一种由国际糖尿病联盟（IDF）提出。
方法
我们从美国国家健康与营养检查调查（2011 - 2016年）中获取了美国非机构化平民人口中2121名亚裔美国成年人的全国代表性样本。我们使用ATP III和IDF定义计算了年龄调整后的、按性别划分的MetS患病率以及每个MetS组分。
结果
基于IDF定义，研究样本中的亚裔美国男性MetS患病率为39.26%，亚裔美国女性为39.66%。基于ATP III定义，我们样本中的男性MetS患病率为39.38%，女性为36.11%。我们发现IDF和ATP III定义在识别亚裔美国成年人的MetS方面具有良好的一致性。仅由IDF定义诊断为MetS的人群的体重指数（BMI）和腰围显著高于仅由ATP III定义诊断为MetS的人群。IDF定义还能更好地预测空腹胰岛素升高。
结论
对于筛查和评估亚裔美国成年人患CVD和糖尿病的风险，IDF定义比ATP III定义更相关。未来的研究应检查不同亚裔群体中MetS患病率的差异，以促进制定适合文化背景的策略，改善亚裔美国人中MetS的预防和检测。
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