Doherty M J, Kim Wonsuk, Youn C E, Haltiner A M, Oakley J C, Drane D L, Miller J W
Swedish Epilepsy Center, 550 17th Avenue, Suite 540, Seattle, WA 98122, USA.
Epilepsy Behav. 2009 Sep;16(1):80-1. doi: 10.1016/j.yebeh.2009.06.023. Epub 2009 Jul 15.
In a prior study of epilepsy and atmospheric pressure, we were able to show a small association between changes in atmospheric pressure and increased seizure frequency in consecutive patients with epilepsy undergoing video telemetry. In this study, we used a larger data set of similar patients undergoing telemetry at another Seattle institution, and examined the possible impact of atmospheric pressure (AP) changes on seizure onset in subtypes of seizures (focal, generalized, and nonepileptic). Comparisons were made between AP score at time of seizure onset and AP score at selected time ranges prior to the event (hour of seizure and 3, 6, and 24 hours prior) and a random sample of AP scores collected over similar time frames using nonparametric testing with correction for multiple comparisons. We could find no evidence to suggest atmospheric pressure changes made seizure occurrence more likely in any of the seizure groups across any of the time periods.
在先前一项关于癫痫与大气压力的研究中，我们能够证明，在接受视频遥测的连续性癫痫患者中，大气压力变化与癫痫发作频率增加之间存在微弱关联。在本研究中，我们使用了西雅图另一机构中接受遥测的类似患者的更大数据集，并研究了大气压力（AP）变化对癫痫发作亚型（局灶性、全身性和非癫痫性）发作起始的可能影响。对癫痫发作起始时的AP评分与事件发生前选定时间范围（癫痫发作时刻以及发作前3、6和24小时）的AP评分进行了比较，并使用非参数检验对多个比较进行校正，对在相似时间框架内收集的AP评分随机样本进行了比较。我们找不到证据表明在任何时间段内，大气压力变化会使任何癫痫发作组的癫痫发作更有可能发生。
