Sports Trauma Clinic, Aarhus University Hospital, Aarhus, Denmark.
Knee Surg Sports Traumatol Arthrosc. 2010 Jan;18(1):79-84. doi: 10.1007/s00167-009-0865-2. Epub 2009 Jul 16.
Developing bio-absorbable interference screws for anterior cruciate ligament (ACL) reconstruction has proven to be a challenging task. The aim of this study was to investigate the osteogenetic response of poly-lactide carbonate (PLC) interference screws in ACL reconstruction in humans. Ten patients (median age, 28 years) underwent arthroscopic ACL reconstruction with semitendinosus/gracilis tendon graft and a PLC interference screw. The patients were scanned with a multi-slice CT scanner 2 weeks and 1 year postoperatively. Fourteen days postoperatively a mean tunnel widening of 78% [52%; 110%] was observed. At 1-year follow-up, the mean tunnel widening was 128% [84%; 180%]. No sign of bone replacement or bone ingrowth was observed. Factors such as accelerated rehabilitation, micro-motions, and early screw degradation might be responsible for this large tunnel widening. Our results demonstrate the difficulty in translation of preclinical data. This study illustrates the need for extensive preclinical investigation of new materials for clinical purposes.
开发用于前交叉韧带 (ACL) 重建的生物可吸收干扰螺钉已被证明是一项具有挑战性的任务。本研究旨在研究聚乳酸碳酸酯 (PLC) 干扰螺钉在 ACL 重建中的成骨反应。10 名患者（中位年龄 28 岁）接受了关节镜下 ACL 重建，使用半腱肌/股薄肌腱移植物和 PLC 干扰螺钉。患者在术后 2 周和 1 年时使用多层 CT 扫描仪进行扫描。术后 14 天，平均隧道增宽 78%[52%；110%]。在 1 年的随访中，平均隧道增宽为 128%[84%；180%]。未观察到骨替代或骨内生长的迹象。加速康复、微动和早期螺钉降解等因素可能是导致这种大隧道增宽的原因。我们的结果表明将临床前数据转化为临床应用具有一定难度。本研究说明了为临床目的对新型材料进行广泛的临床前研究的必要性。
