Unidad de Investigación Médica en Farmacología de Productos Naturales, UMAE Hospital de Pediatría, Centro Médico Nacional Siglo XXI, IMSS, México DF, México.
Phytother Res. 2010 May;24(5):662-5. doi: 10.1002/ptr.2938.
Chia (Salvia polystachya Ort., Lamiaceae) is frequently used in Mexican traditional medicine to treat dysentery. In this study the main neo-clerodane diterpenes (polystachynes A, B and D, as well as linearolactone) were isolated from the aerial parts of chia, and their antiprotozoal activities toward Entamoeba histolytica and Giardia lamblia trophozoites were evaluated in vitro. Linearolactone was the most potent antiamoebic and antigiardial compound with IC(50) values of 22.9 microM for E. histolytica and 28.2 microM for G. lamblia. Polystachynes A, B and D, showed moderate antiprotozoal activity against both protozoans with IC(50) values ranging from 117.0 to 160.6 microM for E. histolytica and from 107.5 to 134.7 microM for G. lamblia. These data suggest that linearolactone may play an important role in the antidiarrhoeal activity of S. polystachya.
植物chia（唇形科鼠尾草属植物）常被墨西哥传统医学用于治疗痢疾。在这项研究中，主要的新 clerodane 二萜（polystachynes A、B 和 D 以及线性内酯）从 chia 的地上部分分离出来，并在体外评估了它们对溶组织内阿米巴和蓝氏贾第鞭毛虫滋养体的抗原生动物活性。线性内酯是最有效的抗变形虫和抗贾第鞭毛虫化合物，对溶组织内阿米巴的 IC50 值为 22.9 μM，对蓝氏贾第鞭毛虫的 IC50 值为 28.2 μM。Polystachynes A、B 和 D 对两种原生动物均表现出中等的抗原生动物活性，对溶组织内阿米巴的 IC50 值范围为 117.0 至 160.6 μM，对蓝氏贾第鞭毛虫的 IC50 值范围为 107.5 至 134.7 μM。这些数据表明，线性内酯可能在 S. polystachya 的抗腹泻活性中发挥重要作用。
