Young Researchers and Elite Club, Shahrekord Branch, Islamic Azad University, Shahrekord, Iran.
School of Medicine, Bam University of Medical Sciences, Bam, Iran.
Parasitology. 2021 May;148(6):672-684. doi: 10.1017/S0031182021000172. Epub 2021 Feb 4.
Amoebiasis has emerged as a major health problem worldwide. It is endemic in the present scenario is different and sub-tropical regions especially in Asia, Latin America and also in Africa. Causative of amoebiasis is a protozoan known as Entamoeba histolytica. We screened all the databases such as PubMed, Science Direct, Medline and Google Scholar by using the keywords ‘anti-Entamoeba histolytica activity of medicinal plants, anti-Entamoeba histolytica activity of herbal drugs, the anti-amoebic activity of natural drugs’. In the present study, we found 7861 articles, where all articles were screened for bias analysis and included 32 full-matching articles in total reporting the use of medicinal plants as a remedy for amoebiasis. Through these articles, we found 42 herbs having anti-amoebic activity. In bias analysis, we also found four articles under high bias risk. In our study, seven medicinal plants were concluded to possess the most potent anti-amoebic activity based on their IC50 value, which was less than 1 μg mL−1. On bias analysis, we found four articles with high bias risk, hence these studies can be repeated for better results.
阿米巴病已成为全球主要的健康问题。在当前情况下，它在不同的地区和亚热带地区流行，特别是在亚洲、拉丁美洲，也在非洲。引起阿米巴病的病原体是一种原生动物，称为溶组织内阿米巴。我们通过使用关键词“药用植物抗溶组织内阿米巴活性、草药抗溶组织内阿米巴活性、天然药物抗阿米巴活性”，在 PubMed、Science Direct、Medline 和 Google Scholar 等所有数据库中进行了筛选。在本研究中，我们发现了 7861 篇文章，对所有文章进行了偏倚分析，共纳入了 32 篇完全匹配的文章，报道了药用植物作为治疗阿米巴病的方法。通过这些文章，我们发现了 42 种具有抗阿米巴活性的草药。在偏倚分析中，我们还发现了 4 篇高偏倚风险的文章。在我们的研究中，根据 IC50 值（小于 1 μg mL−1），有七种药用植物被认为具有最强的抗阿米巴活性。在偏倚分析中，我们发现了 4 篇高偏倚风险的文章，因此可以重复这些研究以获得更好的结果。
