Bastion Y, Thomas X, Felman P, Campos L, Charrin C, Coiffier B
Hematology Service, Centre Hospitalier Lyon-Sud, Pierre-Bénite, France.
Leukemia. 1991 Nov;5(11):1006-9.
We describe a patient in whom the concomitant diagnosis of refractory anemia with excess of blasts (16% on initial marrow examination) and chronic lymphocytic leukemia was made more than 9 years ago. The myeloid clone showed a complex karyotypic abnormality. Evolution has so far been remarkably stable, without transformation into acute leukemia. Clonogenic assays showed that patient's serum inhibited the patient's own granulocyte-macrophage colony-forming units (CFU-GM). This inhibition was also present for a control subject's CFU-GM and acute myeloid leukemia clonogenic cells. This raises the problem of a down-regulation of the myeloid clone by the malignant lymphoid clone in this patient, and the possible mechanisms for this are discussed.
我们描述了一位患者，9年多前该患者被同时诊断为难治性贫血伴原始细胞增多（初始骨髓检查时原始细胞占16%）和慢性淋巴细胞白血病。髓系克隆显示出复杂的核型异常。迄今为止，病情进展一直非常稳定，未转化为急性白血病。集落形成试验显示，患者血清抑制了患者自身的粒-巨噬细胞集落形成单位（CFU-GM）。这种抑制作用在对照受试者的CFU-GM和急性髓系白血病集落形成细胞中也存在。这就提出了该患者中恶性淋巴系克隆对髓系克隆进行下调的问题，并对其可能机制进行了讨论。
