Gardais J
Laboratoire de Cyto-Hématologie, Centre Départemental de Transfusion, Angers, France.
J Clin Pathol. 1993 Feb;46(2):177-9. doi: 10.1136/jcp.46.2.177.
A case of abnormal chromatin clumping (ACC) which arose during the course of a myelodysplastic/myeloproliferative syndrome is described in a 61 year old woman who died of haemorrhage 43 months after diagnosis. Mature granulocytes exhibited the same nuclear abnormality described in other patients reported. Unusually, she presented with advanced splenomegaly and lymphadenopathy. This case was the third example of ACC in lymphocytes, the first with clinically confirmed lymphadenopathy. Diagnosis of this subset can be based on: older age; short duration of symptoms; no specific karyotypic damage; non-rearranged bcr; proliferative growth pattern in vitro; numerous circulating myelocytes; profound thrombocytopenia.
本文描述了一例在骨髓增生异常/骨髓增殖性综合征病程中出现的染色质异常聚集（ACC）病例。患者为一名61岁女性，诊断后43个月死于出血。成熟粒细胞表现出与其他报道患者中描述的相同核异常。不同寻常的是，她表现为晚期脾肿大和淋巴结病。该病例是淋巴细胞中ACC的第三个实例，首例伴有临床确诊的淋巴结病。该亚组的诊断可基于：年龄较大；症状持续时间短；无特定核型损伤；bcr未重排；体外增殖生长模式；大量循环髓细胞；严重血小板减少症。
