高敏C反应蛋白浓度与冠状动脉病变的血管造影特征

Highly sensitive C-reactive protein concentration and angiographic characteristics of coronary lesion.

作者信息

Irfan Ghazala, Ahmad Mansoor

机构信息

Department of Cardiology, Liquat National Hospital, Karachi, Pakistan.

出版信息

J Ayub Med Coll Abbottabad. 2008 Jul-Sep;20(3):100-3.

PMID:19610530

Abstract

BACKGROUND

The role of inflammation in all stages of atherosclerotic disease is increasingly recognized especially in last few years. The chronic inflammatory process can develop to an acute clinical event by the induction of plaque rupture and therefore cause acute coronary syndrome. Creactive protein is a strong predictor of clinical outcome in coronary artery disease and inflammation has been implicated in the process. We aimed to evaluate the relationship between pre-procedural highly sensitive C-Reactive Protein (hs-CRP) and angiographic features in patients with acute coronary syndrome.

METHODS

In a cross-sectional study, we examined 100 patients admitted with acute coronary syndrome and assessed the relationship between preprocedural hs-CRP concentration and coronary angiographic lesions.

RESULTS

One hundred patients with acute coronary syndrome were assessed. Some of the results were as follows: mean age 59.26 +/- 11.04, 64% male and 36% female. 34% of patients had unstable angina, 43% had Non ST elevation myocardial infarction (NSTEMI) and 23% had ST elevation myocardial infarction (STEMI). The mean value of hs-CRP was 4.26 +/- 1.42 mg/dl with highest values in patients eccentric/irregular lesion and patients having macroscopic thrombus (p = 0.01).

CONCLUSION

Among patients with acute coronary syndrome increased levels of hs-CRP correlates with specific high risk coronary artery lesions.

摘要

背景

近年来，炎症在动脉粥样硬化疾病各个阶段的作用日益受到认可。慢性炎症过程可通过斑块破裂诱发发展为急性临床事件，进而导致急性冠状动脉综合征。C反应蛋白是冠状动脉疾病临床预后的有力预测指标，炎症也与此过程相关。我们旨在评估急性冠状动脉综合征患者术前高敏C反应蛋白（hs-CRP）与血管造影特征之间的关系。

方法

在一项横断面研究中，我们检查了100例因急性冠状动脉综合征入院的患者，并评估了术前hs-CRP浓度与冠状动脉造影病变之间的关系。

结果

对100例急性冠状动脉综合征患者进行了评估。部分结果如下：平均年龄59.26±11.04岁，男性占64%，女性占36%。34%的患者患有不稳定型心绞痛，43%患有非ST段抬高型心肌梗死（NSTEMI），23%患有ST段抬高型心肌梗死（STEMI）。hs-CRP的平均值为4.26±1.42mg/dl，在有偏心/不规则病变的患者和有肉眼可见血栓的患者中值最高（p = 0.01）。