Gendenshteĭn E I, Kostin Ia V, Volkova N D
Kardiologiia. 1977 Apr;17(4):116-20.
Experiments have demonstrated that Alfeprol arrests atrial fibrillation in dogs induced by electric stimulation of the heart, and atrial fibrillation in cats modelled by Akonitine application; it suppresses ventricular tachycardia in dogs occurring following an occlusion of the branches of coronary arteries, and in cats when induced by strophantin intoxication; it prevents fatal ventricular fibrillation in rats poisoned by calcium chloride. The antiarrhythmic effect of Anaprille was not so persistent and manifested itself only in cases of some particular rhythm disorders. Ornid displayed no antiarrhythmic activity. The blocking of adrenergic innervation of the heart by means of beta-adrenergic blockers (Alfeprol, Anaprilline) and sympatholytic (Reserpine, Ornid) considerably increased the animals tolerance of the toxic effect of strophantin, decreasing its arrhythmogenic effect in particular. The mechanisms of the antiarrhythmic effect of antiadrenergic agents are discussed along with the possibilities of their employment for the correction of cardiac sensitivity of glycosides.
实验表明，阿尔费普罗能使电刺激心脏诱发的犬房颤以及用乌头碱造模的猫房颤停止；它能抑制冠状动脉分支闭塞后犬出现的室性心动过速，以及毒毛旋花子苷中毒诱发的猫室性心动过速；它能预防氯化钙中毒大鼠的致命性室颤。阿那普利的抗心律失常作用不那么持久，仅在某些特定的节律紊乱情况下才表现出来。奥尼德没有抗心律失常活性。通过β - 肾上腺素能阻滞剂（阿尔费普罗、阿那普利）和抗交感神经药（利血平、奥尼德）阻断心脏的肾上腺素能神经支配，可显著提高动物对毒毛旋花子苷毒性作用的耐受性，尤其降低其致心律失常作用。文中讨论了抗肾上腺素能药物抗心律失常作用的机制以及将其用于纠正心脏对糖苷敏感性的可能性。
