Hardy John G, Scheibel Thomas R
Lehrstuhl für Biomaterialien, Universität Bayreuth, Universitätsstrasse 30, 95440 Bayreuth, Germany.
Biochem Soc Trans. 2009 Aug;37(Pt 4):677-81. doi: 10.1042/BST0370677.
The biocompatibility and biodegradability of natural silk fibres and the benign conditions under which they (with impressive mechanical properties) are produced represent a biomimetic ideal. This ideal has inspired people in both academia and industry to prepare silk-mimetic polymers and proteins by chemical and/or biotechnological means. In the present paper, we aim to give an overview of the design principles of such silk-inspired polymers/proteins, their processing into various materials morphologies, their mechanical and biological properties, and, finally, their technical and biomedical applications.
天然丝纤维的生物相容性和生物降解性，以及它们（具有令人印象深刻的机械性能）生产时的温和条件代表了一种仿生理想状态。这一理想状态激发了学术界和工业界的人士通过化学和/或生物技术手段制备仿丝聚合物和蛋白质。在本文中，我们旨在概述此类受丝启发的聚合物/蛋白质的设计原则、它们加工成各种材料形态的过程、它们的机械和生物学特性，以及最后它们的技术和生物医学应用。
