MacIntosh Ana C, Kearns Victoria R, Crawford Aileen, Hatton Paul V
Centre for Biomaterials and Tissue Engineering, School of Clinical Dentistry, University of Sheffield, Sheffield, UK.
J Tissue Eng Regen Med. 2008 Mar-Apr;2(2-3):71-80. doi: 10.1002/term.68.
Silks have been proposed as potential scaffold materials for tissue engineering, mainly because of their physical properties. They are stable at physiological temperatures, flexible and resist tensile and compressive forces. Bombyx mori (silkworm) cocoon silk has been used as a suture material for over a century, and has proved to be biocompatible once the immunogenic sericin coating is removed. Spider silks have a similar structure to silkworm silk but do not have a sericin coating. This paper provides a general overview on the use of silk protein in biomaterials, with a focus on skeletal tissue engineering.
丝绸已被提议作为组织工程的潜在支架材料，主要是因其物理特性。它们在生理温度下稳定、柔韧且能抵抗拉伸和压缩力。家蚕茧丝作为缝合材料已使用了一个多世纪，并且一旦去除具有免疫原性的丝胶涂层，已证明其具有生物相容性。蜘蛛丝与家蚕丝结构相似，但没有丝胶涂层。本文概述了丝蛋白在生物材料中的应用，重点是骨骼组织工程。
