Department of Internal Medicine, Pojen General Hospital, Taipei, Taiwan.
Cephalalgia. 2010 Apr;30(4):433-8. doi: 10.1111/j.1468-2982.2009.01935.x. Epub 2010 Feb 15.
Using a 3-year nationwide population-based database, this study aims to examine the risk of adverse pregnancy outcomes in women with migraines, including low birthweight (LBW), preterm birth, infants born small for gestational age, Caesarean section (CS) and pre-eclampsia. We identified a total of 4911 women with migraines who gave birth from 2001 to 2003, together with 24,555 matched women as a comparison cohort. Multivariate logistic regression analyses showed that after adjusting for potential confounders, the odds ratios were 1.16 [95% confidence intervals (CI) = 1.03-1.31, P = 0.014] for LBW, 1.24 (95% CI = 1.13-1.39, P < 0.001) for preterm births, 1.16 (95% CI = 1.07-1.24, P < 0.001) for CS and 1.34 (95% CI = 1.02-1.77, P = 0.027) for pre-eclampsia for women with migraines compared with unaffected mothers. We conclude that women with migraines were at increased risk of having LBW, preterm babies, pre-eclampsia and delivery by CS, compared with unaffected mothers.
本研究使用了一个为期 3 年的全国性基于人群的数据库，旨在探讨偏头痛女性不良妊娠结局的风险，包括低出生体重（LBW）、早产、小于胎龄儿、剖宫产（CS）和子痫前期。我们共确定了 4911 名偏头痛女性，她们在 2001 年至 2003 年期间分娩，同时匹配了 24555 名未受影响的女性作为对照组。多变量逻辑回归分析显示，在校正了潜在混杂因素后，LBW 的比值比为 1.16（95%置信区间 [CI] = 1.03-1.31，P = 0.014），早产的比值比为 1.24（95% CI = 1.13-1.39，P < 0.001），CS 的比值比为 1.16（95% CI = 1.07-1.24，P < 0.001），子痫前期的比值比为 1.34（95% CI = 1.02-1.77，P = 0.027），偏头痛女性与未受影响的母亲相比，发生这些情况的风险更高。我们的结论是，与未受影响的母亲相比，偏头痛女性发生 LBW、早产儿、子痫前期和 CS 分娩的风险增加。
