类风湿关节炎女性不良妊娠结局风险增加：一项全国基于人群的研究。
Increased risk of adverse pregnancy outcomes in women with rheumatoid arthritis: a nationwide population-based study.
机构信息
School of Public Health, Taipei Medical University, 250 Wu-Hsing Street, Taipei 110, Taiwan.
出版信息
Ann Rheum Dis. 2010 Apr;69(4):715-7. doi: 10.1136/ard.2008.105262. Epub 2009 Apr 29.
OBJECTIVE
Using a 3-year nationwide population-based database (2001-3), this study aims to examine the relationship between rheumatoid arthritis (RA) and adverse pregnancy outcomes.
METHODS
The study used the Taiwan National Health Insurance Research Dataset and birth certificate registry. In total, 1912 mothers with RA and 9560 matched comparison mothers were included. Separate conditional logistic regression analyses were carried out to explore the risk of low birthweight (LBW), preterm births, small for gestational age (SGA) infants, preeclampsia and delivery mode (vaginal vs caesarean section (CS)) for the study and comparison groups.
RESULTS
Regression analyses showed that the adjusted odds of LBW, SGA infants, preeclampsia and CS for women with RA were 1.47 (95% CI 1.22 to 1.78), 1.20 (95% CI 1.05 to 1.38), 2.22 (95% CI 1.59 to 3.11) and 1.19 (95% CI 1.07 to 1.31) times, respectively, that of comparison mothers.
CONCLUSION
Women with RA had an increased risk of LBW, SGA babies, preeclampsia and CS compared with unaffected women.
目的
本研究使用了一个为期 3 年的全国性基于人群的数据库（2001-2003 年），旨在探讨类风湿关节炎（RA）与不良妊娠结局之间的关系。
方法
本研究使用了台湾全民健康保险研究数据集和出生证明登记处。共纳入了 1912 名患有 RA 的母亲和 9560 名匹配的对照母亲。分别进行了条件逻辑回归分析，以探讨研究组和对照组中低出生体重（LBW）、早产、小于胎龄儿（SGA）、子痫前期和分娩方式（阴道分娩与剖宫产（CS））的风险。
结果
回归分析显示，患有 RA 的女性发生 LBW、SGA 婴儿、子痫前期和 CS 的调整比值比（OR）分别为 1.47（95%可信区间 1.22 至 1.78）、1.20（95%可信区间 1.05 至 1.38）、2.22（95%可信区间 1.59 至 3.11）和 1.19（95%可信区间 1.07 至 1.31），与对照母亲相比。
结论
与未受影响的女性相比，患有 RA 的女性发生 LBW、SGA 婴儿、子痫前期和 CS 的风险增加。
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