Barrios Vivencio, Escobar Carlos, Echarri Rocio, Matalí Arantxa
Department of Cardiology, Hospital Ramón y Cajal, Madrid, Spain.
J Cardiometab Syndr. 2009 Spring;4(2):72-5. doi: 10.1111/j.1559-4572.2008.00041.x.
The authors examined the clinical profile of the hypertensive population with the metabolic syndrome (MetS) and elevated pulse pressure (PP) in a sample of 5866 patients (3291 women and 2575 men) included in a large hypertension survey performed in primary care setting. Elevated PP was defined as >or=80 mm Hg in women and >or=75 mm Hg in men; 92.7% of women and 87.6% of men had normal PP values. Patients with higher PP levels were older, were more commonly diabetic, and exhibited more frequently target organ damage and associated clinical conditions. Blood pressure was less well controlled in the subgroup of patients with elevated PP: control rates were 4.1% vs 19.2%, P<.001; men, 3.9% vs 19.0%, P<.001; P=NS between sexes. Low-density lipoprotein cholesterol was similarly controlled regardless of PP: control rates were, 17.0% vs 17.8%; in women with high PP vs normal PP and 25.2% vs 25.1% in men with high PP vs normal PP, both P=NS; P<.001 between sexes with high PP. In the patients with high PP, the female subgroup was older, was more obese, and had more left ventricular hypertrophy and fewer associated clinical conditions than did men. The odds ratio of having high PP in women with MetS vs no MetS was 3.13 and in men was 1.9 (both P<.01).
作者在一项针对基层医疗环境中进行的大型高血压调查所纳入的5866例患者（3291名女性和2575名男性）样本中，研究了患有代谢综合征（MetS）且脉压（PP）升高的高血压人群的临床特征。PP升高定义为女性≥80 mmHg，男性≥75 mmHg；92.7%的女性和87.6%的男性PP值正常。PP水平较高的患者年龄更大，更常患糖尿病，且更频繁地出现靶器官损害及相关临床病症。PP升高的患者亚组血压控制较差：控制率分别为4.1%和19.2%，P<0.001；男性为3.9%和19.0%，P<0.001；性别间P值无统计学差异。无论PP如何，低密度脂蛋白胆固醇的控制情况相似：控制率分别为，PP升高的女性与正常PP的女性相比为17.0%和17.（此处原文有误，应为17.8%），PP升高的男性与正常PP的男性相比为25.2%和25.1%，两者P值均无统计学差异；PP升高的性别间P<0.001。在PP升高的患者中，女性亚组比男性年龄更大、更肥胖、左心室肥厚更多且相关临床病症更少。患有MetS的女性与未患MetS的女性相比，PP升高的比值比为3.13，男性为1.9（两者P<0.01）。
