Schilling Matthias, Strecker Jan-Kolja, Ringelstein E Bernd, Kiefer Reinhard, Schäbitz Wolf-Rüdiger
Department of Neurology, University Hospital Münster, Münster, Germany.
Exp Neurol. 2009 Oct;219(2):583-5. doi: 10.1016/j.expneurol.2009.07.003. Epub 2009 Jul 15.
Perivascular and meningeal macrophages are important for immune surveillance in the healthy and the injured brain. Monocyte chemoattractant protein-1 (MCP-1) regulates macrophage migration and permeability of the blood brain barrier. In the present study, we investigated the influence of MCP-1 or/and chemokine receptor 2 (CCR2)-deficiency on macrophage turnover. The results showed no influence of single MCP-1- or CCR-2-deficiency, but double-deficient mice revealed a virtual absence of blood-borne macrophage recruitment. This finding emphasizes that the MCP-1/CCR2 axis is crucially important for macrophage turnover and compensatory mechanisms remain only partially sufficient to sustain regulatory functions.
血管周围和脑膜巨噬细胞对健康及损伤大脑中的免疫监视至关重要。单核细胞趋化蛋白-1（MCP-1）调节巨噬细胞迁移及血脑屏障的通透性。在本研究中，我们调查了MCP-1或/和趋化因子受体2（CCR2）缺陷对巨噬细胞更新的影响。结果显示，单一MCP-1或CCR-2缺陷并无影响，但双缺陷小鼠显示几乎没有血源巨噬细胞募集。这一发现强调，MCP-1/CCR2轴对巨噬细胞更新至关重要，且代偿机制仅部分足以维持调节功能。
