Int J Cardiol. 2010 Nov 5;145(1):122-3. doi: 10.1016/j.ijcard.2009.06.031. Epub 2009 Jul 16.
ACE inhibitors and loop diuretics are treatments of first choice for heart failure, but patients must take their medications regularly to achieve maximum benefit. Adherence is commonly assessed using pill counts, self-report or electronic monitoring, with the latter widely considered the 'gold standard'. We assessed the concordance of these three methods in a sample of 52 elderly patients with heart failure over a six-week period. Substantial differences in adherence were found between the three methods. Adherence by self-report was very high for both ACE-I and diuretic, with little between-person variation. This was, however, uncorroborated by pill count and electronic monitoring. Closer examination of the electronic record suggested that the mean level of adherence overlooked patterns of openings more consistent with adherent behaviour. There seems to be no gold standard for measurement of adherence in this population.
血管紧张素转换酶抑制剂和袢利尿剂是心力衰竭的首选治疗方法，但患者必须规律服药才能获得最大益处。药物依从性通常通过药物计数、自我报告或电子监测来评估，其中后者被广泛认为是“金标准”。我们在一个为期六周的时间里对 52 名老年心力衰竭患者进行了这三种方法的一致性评估。这三种方法的药物依从性存在很大差异。自我报告的 ACE-I 和利尿剂的药物依从性非常高，人与人之间的差异很小。然而，这与药物计数和电子监测并不相符。对电子记录的更仔细检查表明，平均药物依从水平忽略了更符合依从行为的开启模式。在这个人群中，似乎没有测量药物依从性的金标准。
