Fehrenbacher Nicole, Bar-Sagi Dafna, Philips Mark
Department of Cell Biology, NYU School of Medicine, New York, NY 10016, USA.
Mol Oncol. 2009 Aug;3(4):297-307. doi: 10.1016/j.molonc.2009.06.004. Epub 2009 Jun 26.
Signal transduction along the Ras/MAPK pathway has been generally thought to take place at the plasma membrane. It is now evident that the plasma membrane is not the only platform capable of Ras/MAPK signal induction. Fusion of Ras with green fluorescent protein and the development of genetically encoded fluorescent probes for Ras activation have revealed signaling events on a variety of intracellular membranes including endosomes, the Golgi apparatus and the endoplasmic reticulum. Thus, the Ras/MAPK pathway is spatially compartmentalized within cells and this may afford greater complexity of signal output.
一直以来，人们普遍认为沿Ras/MAPK途径的信号转导发生在质膜上。现在很明显，质膜并非唯一能够诱导Ras/MAPK信号的平台。Ras与绿色荧光蛋白的融合以及用于Ras激活的基因编码荧光探针的开发，揭示了包括内体、高尔基体和内质网在内的各种细胞内膜上的信号事件。因此，Ras/MAPK途径在细胞内进行空间分隔，这可能会使信号输出更加复杂。
