中枢作用的非麻醉性镇咳药替皮啶在大鼠强迫游泳试验中产生抗抑郁样作用。
The centrally acting non-narcotic antitussive tipepidine produces antidepressant-like effect in the forced swimming test in rats.
机构信息
Department of Environmental and Molecular Health Sciences, Graduate School of Pharmaceutical Sciences, Kumamoto University, 5-1 Oe-honmachi, Kumamoto 862-0973, Japan.
出版信息
Behav Brain Res. 2009 Dec 14;205(1):315-8. doi: 10.1016/j.bbr.2009.07.004. Epub 2009 Jul 16.
The antidepressant-like effect of tipepidine was studied in rats. Tipepidine at 20 and 40 mg/kg i.p. reduced immobility in the forced swimming test and tipepidine at 40 mg/kg, i.p. increased climbing in the test. The drug at 40 mg/kg, i.p. had no effect on the locomotor activity and motor coordination. These results suggest that tipepidine may be a novel drug with antidepressant-like activity.
研究了替哌啶在大鼠体内的抗抑郁样作用。替哌啶以 20 和 40mg/kg 腹腔注射给药可减少强迫游泳试验中的不动性，且替哌啶以 40mg/kg 腹腔注射给药可增加试验中的攀爬。该药物以 40mg/kg 腹腔注射给药对运动活动和运动协调无影响。这些结果表明，替哌啶可能是一种具有抗抑郁样活性的新型药物。
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