自由基衰老理论：对男性不育的影响。

Free radical theory of aging: implications in male infertility.

机构信息

Center for Reproductive Medicine, Glickman Urological and Kidney Institute, Cleveland Clinic, Cleveland, Ohio 44195, USA.

出版信息

Urology. 2010 Jan;75(1):14-9. doi: 10.1016/j.urology.2009.05.025. Epub 2009 Jul 17.

DOI:10.1016/j.urology.2009.05.025

PMID:19616285

Abstract

This review examines the effect of mitochondrial generation of reactive oxygen species (ROS) and aging on human spermatozoa and seminal antioxidants. We discuss the effect of continuous ROS production on biomarkers of aging, such as germ cell telomeres and telomerase, lipofuscin, and amyloid. These markers may be responsible for telomere shortening and subsequent decrease in sperm count, decline in testosterone concentration, and decline in motility with aging. Excessive ROS can also damage mitochondrial deoxyribonucleic acid and sperm nuclear DNA, contributing to paternally transmitted diseases. ROS generation has a central role in the pathophysiology of age-related decrease in male fertility.

摘要

这篇综述考察了线粒体产生活性氧（ROS）和衰老对人类精子和精液抗氧化剂的影响。我们讨论了持续产生 ROS 对衰老生物标志物的影响，如生殖细胞端粒和端粒酶、脂褐素和淀粉样蛋白。这些标志物可能是导致端粒缩短和随后精子数量减少、睾丸激素浓度下降以及随着年龄增长运动能力下降的原因。过多的 ROS 还会损害线粒体脱氧核糖核酸和精子核 DNA，导致父系遗传疾病。ROS 的产生在与年龄相关的男性生育力下降的病理生理学中起着核心作用。