Vance Russell E, Isberg Ralph R, Portnoy Daniel A
Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA 94720, USA.
Cell Host Microbe. 2009 Jul 23;6(1):10-21. doi: 10.1016/j.chom.2009.06.007.
The dominant conceptual framework for understanding innate immunity has been that host cells respond to evolutionarily conserved molecular features of pathogens called pathogen-associated molecular patterns (PAMPs). Here, we propose that PAMPs should be understood in the context of how they are naturally presented by pathogens. This can be experimentally challenging, since pathogens, almost by definition, bypass host defense. Nevertheless, in this review, we explore the idea that the immune system responds to PAMPs in the context of additional signals that derive from common "patterns of pathogenesis" employed by pathogens to infect, multiply within, and spread among their hosts.
理解固有免疫的主要概念框架一直是宿主细胞对被称为病原体相关分子模式（PAMPs）的病原体进化保守分子特征作出反应。在此，我们提出应从病原体自然呈现PAMPs的方式这一背景下来理解PAMPs。这在实验上可能具有挑战性，因为几乎从定义上来说，病原体都会避开宿主防御。然而，在本综述中，我们探讨了这样一种观点，即免疫系统在来自病原体用于感染宿主、在宿主体内繁殖并在宿主间传播的常见“致病模式”所产生的额外信号背景下对PAMPs作出反应。
