Department of Obstetrics and Gynecology, Women's Health Centre, Assiut University, Assiut, Egypt.
Int J Gynaecol Obstet. 2009 Nov;107(2):117-20. doi: 10.1016/j.ijgo.2009.06.008. Epub 2009 Jul 18.
To assess the effectiveness and tolerability of misoprostol to reduce the amount and duration of vaginal bleeding following surgical evacuation for first trimester spontaneous abortion.
A total of 160 patients who underwent surgical evacuation for first trimester spontaneous abortion between 8 and 12 weeks of pregnancy were randomized into 2 groups to receive either 200 microg of oral misoprostol immediately after evacuation followed every 6 hours for 48 hours or no misoprostol. Pain scores, duration and amount of bleeding, and endometrial thickness were assessed over 10 days.
Women who received misoprostol had significantly fewer bleeding days after evacuation (4.11+/-2.69 vs 5.89+/-3.06; P<0.001), fewer patients reported vaginal bleeding lasting 10 days or more (3.8% vs 15.0%; P=0.014), and endometrial thickness 10 days after evacuation was less (6.25+/-2.38 vs 7.23+/-1.94; P=0.05). Pain scores were comparable in both groups (1.54+/-0.65 vs 1.63+/-0.83; P=0.40) after 10 days.
Oral misoprostol is effective in reducing the prevalence and amount of vaginal bleeding after surgical evacuation for first trimester spontaneous abortion.
评估米索前列醇在减少 8-12 周妊娠行早期人工流产术后阴道出血的量和时间方面的有效性和耐受性。
将 160 例行早期人工流产术的患者随机分为两组，术后立即口服 200μg米索前列醇，每 6 小时一次，共 48 小时；或不使用米索前列醇。术后 10 天评估疼痛评分、出血时间和出血量以及子宫内膜厚度。
使用米索前列醇的患者术后阴道出血天数明显减少（4.11+/-2.69 天比 5.89+/-3.06 天；P<0.001），报告阴道出血持续 10 天或更长时间的患者比例更少（3.8%比 15.0%；P=0.014），术后 10 天的子宫内膜厚度也较低（6.25+/-2.38mm 比 7.23+/-1.94mm；P=0.05）。两组患者术后 10 天的疼痛评分相似（1.54+/-0.65 分比 1.63+/-0.83 分；P=0.40）。
口服米索前列醇可有效减少早期人工流产术后阴道出血的发生率和出血量。
