Aramide T M, Olusegun A K, Akinfolarin A C, Oriola D F
Department of Obstetrics, Gynaecology and Perinatology, Obafemi Awolowo University Teaching Hospitals Complex, Ile-Ife, Osun State, Nigeria.
Niger J Clin Pract. 2014 Jan-Feb;17(1):10-3. doi: 10.4103/1119-3077.122823.
This comparative study was aimed at determining the effectiveness of oral Misoprostol compared with intravenous Ergometrine and intravenous Oxytocin in reducing vaginal bleeding following surgical evacuation for first trimester abortions.
This was a single-blind placebo-controlled study in which patients with first trimester uncomplicated abortions were divided into three groups using computer-generated randomization table. The first group was administered oral Misoprostol, the second group had intravenous Ergometrine, and the third group was administered intravenous Oxytocin. The uterotonic agents were administered before the surgical evacuation was carried out.
There was statistically significant reduction in blood loss after the evacuation in the Misoprostol group ( P < 0.000). There was also significant reduction in the number of days of bleeding in the Misoprostol group (2.00 ± 0.86) compared with 4.43 ± 0.92 and 4.64 ± 1.06 days in the Ergometrine and Oxytocin groups, respectively ( P < 0.000). There were, however, more gastrointestinal side effects in the Misoprostol and Ergometrine groups (60.7% and 57.1%, respectively) compared with the Oxytocin group.
Oral Misoprostol appeared to demonstrate superior efficacy in reducing uterine bleeding after surgical evacuation, compared to the other commonly used uterotonic agents.
本比较研究旨在确定口服米索前列醇与静脉注射麦角新碱和静脉注射缩宫素相比，在减少早孕期人工流产手术清宫术后阴道出血方面的有效性。
这是一项单盲安慰剂对照研究，使用计算机生成的随机分组表将早孕期无并发症流产患者分为三组。第一组给予口服米索前列醇，第二组给予静脉注射麦角新碱，第三组给予静脉注射缩宫素。宫缩剂在手术清宫前给药。
米索前列醇组清宫术后失血量有统计学显著减少（P < 0.000）。米索前列醇组出血天数也显著减少（2.00 ± 0.86天），而麦角新碱组和缩宫素组分别为4.43 ± 0.92天和4.64 ± 1.06天（P < 0.000）。然而，米索前列醇组和麦角新碱组的胃肠道副作用比缩宫素组更多（分别为60.7%和57.1%）。
与其他常用宫缩剂相比，口服米索前列醇在减少手术清宫术后子宫出血方面似乎显示出更高的疗效。
