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Forces and structural limitations of binding of thyrotrophin-releasing factor to the thyrotrophin-releasing receptor: the pyroglutamic acid moiety.

作者信息

Goren H J, Bauce L G, Vale W

出版信息

Mol Pharmacol. 1977 Jul;13(4):606-14.

PMID:196172
Abstract
摘要

相似文献

1
Forces and structural limitations of binding of thyrotrophin-releasing factor to the thyrotrophin-releasing receptor: the pyroglutamic acid moiety.促甲状腺激素释放因子与促甲状腺激素释放受体结合的力及结构限制:焦谷氨酸部分
Mol Pharmacol. 1977 Jul;13(4):606-14.
2
Conformationally restricted TRH analogs: a probe for the pyroglutamate region.构象受限的促甲状腺激素释放激素类似物:焦谷氨酸区域的一种探针
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3
Synthesis of a series of residue 1 (pyroglutamic acid) analogs of thyrotrophin releasing hormone.
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4
Investigations on the binding properties of the nootropic agent pyroglutamic acid.
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Synthesis, receptor binding affinities and alpha-MSH releasing activities of TRH analogues.促甲状腺激素释放激素类似物的合成、受体结合亲和力及α-促黑素细胞激素释放活性
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Binding of TRH, DN-1417 and MK-771 to TRH receptors in the rat brain. Relationship to their central actions.促甲状腺激素释放激素(TRH)、DN - 1417和MK - 771与大鼠脑内TRH受体的结合。及其与中枢作用的关系。
Kurume Med J. 1983;30 Suppl:S45-50. doi: 10.2739/kurumemedj.30.supplement_s45.
7
Role of the extracellular loops of the thyrotropin-releasing hormone receptor: evidence for an initial interaction with thyrotropin-releasing hormone.促甲状腺激素释放激素受体胞外环的作用:与促甲状腺激素释放激素初始相互作用的证据
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Modifications of the pyroglutamic acid and histidine residues in thyrotropin-releasing hormone (TRH) yield analogs with selectivity for TRH receptor type 2 over type 1.促甲状腺激素释放激素(TRH)中焦谷氨酸和组氨酸残基的修饰产生了对2型TRH受体比对1型具有选择性的类似物。
Bioorg Med Chem. 2007 Jan 1;15(1):433-43. doi: 10.1016/j.bmc.2006.09.045. Epub 2006 Oct 10.
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Two novel thioamide analogues of TRH with selective activity on CNS.两种对中枢神经系统具有选择性活性的新型促甲状腺激素释放激素硫代酰胺类似物。
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Modulation of peptide binding to specific receptors on rat pituitary cells by tumor-promoting phorbol esters: decreased binding of thyrotropin-releasing hormone and somatostatin as well as epidermal growth factor.肿瘤促进剂佛波酯对大鼠垂体细胞上特定受体的肽结合的调节作用:促甲状腺激素释放激素、生长抑素以及表皮生长因子的结合减少。
Cancer Res. 1982 Nov;42(11):4375-81.

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The Structural Basis of Peptide Binding at Class A G Protein-Coupled Receptors.A 类 G 蛋白偶联受体中肽结合的结构基础。
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N-terminal pyroglutamate formation in CX3CL1 is essential for its full biologic activity.CX3CL1 的 N 端焦谷氨酸的形成对于其完全的生物学活性是必需的。
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Linked production of pyroglutamate-modified proteins via self-cleavage of fusion tags with TEV protease and autonomous N-terminal cyclization with glutaminyl cyclase in vivo.
通过体内TEV蛋白酶对融合标签的自我切割以及谷氨酰胺环化酶的自主N端环化作用,实现焦谷氨酸修饰蛋白的连锁生产。
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Structural and functional analyses of a glutaminyl cyclase from Ixodes scapularis reveal metal-independent catalysis and inhibitor binding.肩突硬蜱谷氨酰胺环化酶的结构与功能分析揭示了其不依赖金属的催化作用及抑制剂结合情况。
Acta Crystallogr D Biol Crystallogr. 2014 Mar;70(Pt 3):789-801. doi: 10.1107/S1399004713033488. Epub 2014 Feb 22.
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Native pyroglutamation of huwentoxin-IV: a post-translational modification that increases the trapping ability to the sodium channel.天然焦谷氨酸化修饰对华武毒素-IV:一种增加与钠离子通道结合能力的翻译后修饰。
PLoS One. 2013 Jun 24;8(6):e65984. doi: 10.1371/journal.pone.0065984. Print 2013.
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Glutaminyl cyclase knock-out mice exhibit slight hypothyroidism but no hypogonadism: implications for enzyme function and drug development.谷氨酰胺酰环化酶敲除小鼠表现出轻微的甲状腺功能减退症,但没有性腺功能减退症:对酶功能和药物开发的影响。
J Biol Chem. 2011 Apr 22;286(16):14199-208. doi: 10.1074/jbc.M111.229385. Epub 2011 Feb 17.
7
Structures of human Golgi-resident glutaminyl cyclase and its complexes with inhibitors reveal a large loop movement upon inhibitor binding.人高尔基驻留谷氨酰胺环化酶及其与抑制剂复合物的结构揭示了抑制剂结合时的大环运动。
J Biol Chem. 2011 Apr 8;286(14):12439-49. doi: 10.1074/jbc.M110.208595. Epub 2011 Feb 1.
8
Pyroglutamic acid. Non-metabolic formation, function in proteins and peptides, and characteristics of the enzymes effecting its removal.焦谷氨酸。非代谢形成、在蛋白质和肽中的功能以及参与其清除的酶的特性。
Mol Cell Biochem. 1981 Aug 11;38 Spec No(Pt 1):181-90. doi: 10.1007/BF00235695.