Kasacka I
Department of Histology and Embryology, Medical University of Bialystok, Poland.
J Physiol Pharmacol. 2009 Jun;60(2):35-9.
The majority of research for the calcitonin gene-related peptide (CGRP) in the stomach in the hypertension has been devoted to the submucosal blood flow, and no attention has been paid to its quantitative distribution in the gastric neuroendocrine cells. The aim of the present study was to examine the number and distribution of CGRP-containing cells in the pylorus of "two kidney, one clip" (2K1C) renovascular hypertension model in rats. The studies were carried out on the stomach of rats. After 6 week period of the renal artery clipping procedure, eight 2K1C rats developed stable hypertension. The hypertension significantly increased the number of endocrine cells pylorus immunoreactive to calcitonin gene-related peptide (CGRP) antisera. The differences between the hypertensive rats and the control group concerned not only the number of endocrine cells but also their distribution. CGRP participates in the regulation of cardiovascular functions both in normal state and in the pathophysiology of hypertension through interactions with the prohypertensive systems. The changes induced by hypertension in the neuroendocrine cells containing CGRP of the rats are discussed.
在高血压研究中，关于胃中降钙素基因相关肽（CGRP）的大多数研究都集中在黏膜下血流方面，而未关注其在胃神经内分泌细胞中的定量分布。本研究的目的是检测大鼠“双肾一夹”（2K1C）肾血管性高血压模型幽门中含CGRP细胞的数量和分布。研究在大鼠的胃部进行。在肾动脉夹闭手术6周后，8只2K1C大鼠出现了稳定的高血压。高血压显著增加了幽门中对降钙素基因相关肽（CGRP）抗血清呈免疫反应的内分泌细胞数量。高血压大鼠与对照组之间的差异不仅在于内分泌细胞的数量，还在于其分布。CGRP通过与高血压系统相互作用，在正常状态和高血压病理生理学中均参与心血管功能的调节。文中讨论了高血压引起的大鼠含CGRP神经内分泌细胞的变化。
