一般人群中抑郁谱系障碍自杀倾向的预测因素:荷兰精神健康调查和发病研究结果。

Predictors of suicidality in depressive spectrum disorders in the general population: results of the Netherlands Mental Health Survey and Incidence Study.

机构信息

De Gelderse Roos, Mental Health Care, Ede, The Netherlands.

出版信息

Soc Psychiatry Psychiatr Epidemiol. 2010 May;45(5):513-21. doi: 10.1007/s00127-009-0093-6. Epub 2009 Jul 19.

Abstract

OBJECTIVE

The aim was to assess determinants of suicidality (suicidal ideation and suicide attempts) in a general population cohort with depressive spectrum disorders, and to compare determinants for suicidal ideation and determinants for suicide attempts in this cohort.

METHOD

The Netherlands Mental Health Survey and Incidence Study is a epidemiologic survey in the adult population (N = 7,076), using the Composite International Diagnostic Interview (CIDI).

RESULTS

In a cohort of 586 persons with a depressive spectrum disorder, 97 (16.6%) reported suicidal ideation and 19 (3.2%) suicide attempts in a period of 2 years. In a multivariate model, male gender (OR 0.54, 95% CI 0.30-0.99, p = 0.05), longer (>13 months) duration of depression (OR 2.86, 95%CI 1.21-6.73, p = 0.02; OR 2.71, 95% CI 1.24-5.91, p = 0.01), anhedonia (OR 2.00, 95% CI 1.01-5.91, p = 0.05), feeling worthless (OR 1.99, 95% CI 1.05-3.74, p = 0.03), comorbid anxiety (OR 2.46, 95% CI 1.38-4.40, p < 0.01), previous suicidal ideation (OR 3.50, 95% CI 1.96-6.24, p < 0.001) and use of professional care (OR 1.96, 95% CI 1.01-3.79, p = 0.05) were significantly related to suicidality. Determinants of suicidal ideation differed from determinants of suicide attempts.

LIMITATIONS

Suicidality (and not actual suicides) was assessed with only two questions from the CIDI and some determinants for suicidality were assessed in the same time period as suicidality.

CONCLUSIONS

Features of depression were the most important determinants of suicidality in a depressive spectrum cohort. Determinants for suicidal ideation differed from suicide attempts. These findings could be helpful in identifying those who need more intense treatment strategies in order to prevent suicidality and eventually suicide.

摘要

目的

评估具有抑郁谱障碍的一般人群队列中自杀意念(自杀意念和自杀未遂)的决定因素,并比较该队列中自杀意念的决定因素和自杀未遂的决定因素。

方法

荷兰精神健康调查和发病率研究是一项对成年人群(N=7076)进行的流行病学调查,使用复合国际诊断访谈(CIDI)。

结果

在一个有抑郁谱障碍的 586 人队列中,97 人(16.6%)在 2 年内报告有自杀意念,19 人(3.2%)有自杀未遂。在多变量模型中,男性(OR 0.54,95%CI 0.30-0.99,p=0.05)、抑郁持续时间较长(>13 个月)(OR 2.86,95%CI 1.21-6.73,p=0.02;OR 2.71,95%CI 1.24-5.91,p=0.01)、快感缺失(OR 2.00,95%CI 1.01-5.91,p=0.05)、自我价值感降低(OR 1.99,95%CI 1.05-3.74,p=0.03)、合并焦虑症(OR 2.46,95%CI 1.38-4.40,p<0.01)、既往自杀意念(OR 3.50,95%CI 1.96-6.24,p<0.001)和专业护理的使用(OR 1.96,95%CI 1.01-3.79,p=0.05)与自杀意念显著相关。自杀意念的决定因素与自杀未遂的决定因素不同。

局限性

仅使用 CIDI 的两个问题评估自杀意念(而非实际自杀),且一些自杀意念的决定因素与自杀意念处于同一时期。

结论

抑郁特征是抑郁谱队列中自杀意念的最重要决定因素。自杀意念的决定因素与自杀未遂不同。这些发现可能有助于确定那些需要更强化治疗策略以预防自杀意念并最终预防自杀的人群。

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